Search for dissertations about: "mRNA turnover"

Showing result 6 - 10 of 40 swedish dissertations containing the words mRNA turnover.

  2. 6. Genetics and Growth Regulation in Salmonella enterica

    Author : Jessica M. Bergman; Diarmaid Hughes; Dan I. Andersson; Måns Ehrenberg; Stanley Maloy; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tufA; tufB; EF-Tu; ppGpp; Stringent response; RNase E; RNA turnover; Post-transcriptional regulation; rpoB; rpoS; Growth in stationary phase; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Mikrobiologi; Microbiology; Molekylär genetik; Molecular Genetics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

    Abstract : Most free-living bacteria will encounter different environments and it is therefore critical to be able to rapidly adjust to new growth conditions in order to be competitively successful. Responding to changes requires efficient gene regulation in terms of transcription, RNA stability, translation and post-translational modifications. READ MORE

  4. 7. On the Regulation of Ornithine Decarboxylase

    Author : Eva Lövkvist Wallström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fysiologi; Physiology; Crithidia fasciculata.; polyamines; Ornithine decarboxylase; translational control; osmolarity; untranslated region; COS cells; CHO cells; transfection; protein turnover; PEST region;

    Abstract : The polyamines putrescine, spermidine and spermine have been shown to be involved in cell growth and differentiation, and are considered to be crucial components of the living cell. The synthesis of polyamines in the cell is strictly regulated. READ MORE

  5. 8. Molecular regulation of rat histidine decarboxylase

    Author : Christine Dartsch; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physiology; omeprazole; antiserum; fetal rat liver; COS-7 cells; purification; bacterial expression; protein turnover; ECL cells; gastric mucosa; gastrin; histdine decarboxylase; histamine; Fysiologi; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : Histamine is involved in a variety of physiological processes like gastric acid secretion, inflammation and neurotransmission. The production of histamine is catalysed by the enzyme histidine decarboxylase (HDC), which is a strongly regulated enzyme. READ MORE

  6. 9. Targeting RNA by the Antisense Approach and a Close Look at RNA Cleavage Reaction

    Author : Jharna Barman; Lars Baltzer; Roger Strömberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; mRNA targeting; antisense oligonucleotides; target affinity; RNase H; Michaelis-Menten kinetics; exo-nuclease stability; NMR; pH titration; alkaline hydrolysis; Organisk kemi;

    Abstract : This thesis summarizes the results of studies on two aspects of nucleic acids. Chemically modified antisense oligonucleotides (AONs) have been evaluated with regards to their suitability for mRNA targeting in an antisense approach (Paper I – III). READ MORE

  7. 10. Simplified Nonsense: New Methods for Interrogating NMD

    Author : Hanna Alalam; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mRNA degradation; metabolic labeling; nonsense-mediated decay; Major protease; SARS-CoV-2;

    Abstract : Nonsense mediated decay (NMD) is a pathway that regulates RNA turnover. Since its discovery, this pathway has been implicated in a variety of cellular processes ranging from differentiation to the restriction of viral replication. READ MORE