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Showing result 1 - 5 of 1787 swedish dissertations matching the above criteria.

  2. 1. mRNA degradation factors as regulators of the gene expression in Saccharomyces cerevisiae

    Author : Mridula Muppavarapu; Tracy Nissan; Per Sunnerhagen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA decapping; mRNA degradation; Pat1; Edc3; Lsm4; Lsm1-7; P bodies; Dcp2; Transcription; Ribosome biogenesis; Exosome.; molekylärbiologi; Molecular Biology;

    Abstract : Messenger RNA degradation is crucial for the regulation of eukaryotic gene expression. It not only modulates the basal mRNA levels but also functions as a quality control system, thereby controlling the availability of mRNA for protein synthesis. READ MORE

  4. 2. Characterization of RNA exosome in Insect Cells : Role in mRNA Surveillance

    Author : Viktoria Hessle; Neus Visa; Maria Carmo-Fonseca; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell nucleus; nuclear bodies; mRNA surveillance; cotranscriptional assembly; Rrp6; Rrp4; mRNP; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : The exosome, an evolutionarily conserved protein complex with exoribonucleolytic activity, is one of the key players in mRNA quality control. Little is known about the functions of the exosome in metazoans. We have studied the role of the exosome in nuclear mRNA surveillance using Chironomus tentans and Drosophila melanogaster as model systems. READ MORE

  5. 3. Spatial control of mRNA stability in yeast

    Author : Susanne Huch; Tracy Nissan; Anders Byström; Anders Virtanen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mRNA stability; P bodies; mRNA turnover; gene regulation; decapping factors; molekylärbiologi; Molecular Biology;

    Abstract : The degradation of mRNA is an important modulator of gene expression and the ultimate fate of messenger mRNA. Important steps in the degradation of mRNA include initial shortening of its poly(A) tail followed by the subsequent removal of the m7G cap. These two processes are linked temporally as well as spatially. READ MORE

  6. 4. Studies on mRNA turnover in bacteria

    Author : Martin Persson; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; aprE; GlpP; glpD; mRNA secondary structure; Bacillus subtilis; mRNA stability; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Genetic information, which is stored in DNA, is transferred to messenger RNA (mRNA) in a process called transcription. mRNAs are then translated by ribosomes into proteins which, with some important exceptions, catalyze chemical reactions in cells. Since cells must be able to adapt to changes in the environment, mRNAs must be unstable. READ MORE

  7. 5. High-resolution Studies of mRNA Expression in Brain : A Search for Genes Differently Expressed in Schizophrenia

    Author : Anja Castensson; Elena Jazin; Terence Speed; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mRNA; gene expression; real-time RT-PCR; schizophrenia; 5-HT serotonin receptor 2C; brain; psychiatric genetics; Genetik; Clinical genetics; Klinisk genetik;

    Abstract : Gene expression differences between patients and controls can be used to find susceptibility genes and drug targets for a disease. High-resolution strategies are required because the differences between the investigated groups may be small and numerous factors may affect the mRNA quantity. READ MORE