Search for dissertations about: "mTOR"
Showing result 1 - 5 of 100 swedish dissertations containing the word mTOR.
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1. Molecular Mechanisms of the DEK Protein in Leukemia
Abstract : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. READ MORE
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2. β-Adrenergic Signalling Through mTOR
Abstract : Adrenergic signalling is part of the sympathetic nervous system and is activated upon stimulation by the catecholamines epinephrine and norepinephrine. This regulates heart rate, energy mobilization, digestion and helps to divert blood flow to important organs. READ MORE
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3. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma
Abstract : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. READ MORE
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4. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects
Abstract : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. READ MORE
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5. Glucose- and hypoxia-regulated insulin gene expression
Abstract : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. READ MORE