Search for dissertations about: "mTOR"

Showing result 11 - 15 of 100 swedish dissertations containing the word mTOR.

  2. 11. Regulation of autophagy and mTOR during Semliki Forest virus infection

    Author : Kai Eng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Semliki Forest virus (SFV) infection causes dramatic changes to the infected cell. For example, synthesis of most cellular proteins shuts off within 4 hours. The cell launches an antiviral response, forms stress granules and, as we found in the work leading up to this thesis, accumulates autophagosomes. READ MORE

  4. 12. Glioneuronal tumours in childhood : Clinical picture, long-term outcome and possible new treatments

    Author : Christoffer Ehrstedt; Gunnar Ahlsten; Bo Strömberg; Ann-Margret Rydell; Anja Smits; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioneuronal tumour; ganglioglioma; dysembryoplastic neuroepithelial tumour; childhood; cognition; psychosocial; HRQoL; outcome; mTOR pathway; somatostatin receptor; Pediatrik; Pediatrics;

    Abstract : Background: Glioneuronal tumours are a subgroup of low-grade tumours of the central nervous system (CNS), often causing epilepsy. Overall survival is excellent, but data regarding long-term seizure outcome and late effects are scarce. READ MORE

  5. 13. Unlocking the Role Of Orphan Solute Carrier SLC38A10 In Brain Metabolism : The SLC38A10 transporter in nutrient and metabolic regulation

    Author : Rekha Tripathi; Robert Fredriksson; Manuel Palacín; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC38A10 transporter; SLC38 family; ER Golgi localization; Amino acid starvation; Nutrient sensing; mTOR signaling; Transcriptomic; Protein array; Metabolomics; Ingenuity Pathway Analysis; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Membrane transporters are the primary gatekeepers of cells and regulate the transport of nutrients, metabolites, ions, water, and neurotransmitters into and across the human cells. The solute carrier transporters (SLCs) are the most prominent transporters, comprising 430 members divided into 65 subfamilies. READ MORE

  6. 14. Clinical potential of the mTOR effectors S6K1, S6K2 and 4EBP1 in breast cancer

    Author : Elin Karlsson; Olle Stål; Anna-Lotta Hallbeck; Patrik Lundström; Catharina Larsson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The prognosis of patients diagnosed with breast cancer has been considerably improved in the latest 25 years, as a result of continuous development of diagnostics and treatment regimens. Though, tumour diseases, for woman mainly lung cancer and breast cancer, still constitute of the most common causes of death in developed countries, following heart diseases. READ MORE

  7. 15. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

    Author : Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. READ MORE