Search for dissertations about: "mTOR"

Showing result 21 - 25 of 100 swedish dissertations containing the word mTOR.

  2. 21. Intracellular signaling in human skeletal muscle following different modes of exercise

    Author : Henrik Mascher; Eva Blomstrand; Jan Henriksson; Jørgen Jensen; Gymnastik- och idrottshögskolan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Medicin Teknik; Medicine Technology;

    Abstract : Resistance and endurance exercise when performed regularly will cause specific adaptations in human skeletal muscle. Resistance exercise is known to increase strength and muscle mass while endurance training increases vascularisation and mitochondrial density which results in enhanced oxidative capacity. READ MORE

  4. 22. To catch a killer : on the mechanisms of interferon alpha induced apoptosis

    Author : Lena Thyrell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances induce apoptosis is still incomplete, and so is the reason for the great variation in cellular sensitivity to these drugs. READ MORE

  5. 23. Developing analytical tools to investigate the role of translation in homeostasis and disease

    Author : Christian Oertlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transcriptome-wide studies of translation efficiencies are required to improve understanding of translational regulation and its role in homeostatic mechanisms. In Study 1, we developed an algorithm for analysis of translation efficiency, called anota2seq. READ MORE

  6. 24. Novel experimental targeted therapy of neuroblastoma

    Author : Lova Perup Segerström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuroblastoma, a malignancy of the sympathetic nervous system, is the most common solid extracranial tumor of infancy and is responsible for around 15% of the cancer-related deaths in children. For the entire group the survival has increased over the last decades, but despite today's intense muti-modal therapy the survival of high-risk neuroblastomas lies just around 50%. READ MORE

  7. 25. Ribosome biogenesis during skeletal muscle hypertrophy

    Author : Ferdinand von Walden; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Muscle adaptation to chronic resistance exercise (RE) is the result of a cumulative effect on gene expression and protein content. Following a bout of RE, muscle protein synthesis increases and, if followed by consecutive bouts (training), protein accretion and muscle hypertrophy develops. READ MORE