Search for dissertations about: "macrolides"

Showing result 1 - 5 of 9 swedish dissertations containing the word macrolides.

  1. 1. Macrolide Antibiotics in Bacterial Protein Synthesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Martin Lovmar; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; protein synthesis; macrolides; resistance; initiation of translation; non-competitive inhibitors; kinetics; translation accuracy; proof-reading; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : Macrolides are a large group of clinically relevant antibiotics that inhibit protein synthesis by binding to the large ribosomal subunit in the peptide exit tunnel, close to the peptidyl transferase center (PTC). We have shown that the peptide length of the resulting peptidyl-tRNA drop-off products is proportional to the distance between the PTC and the respective macrolide in the tunnel. READ MORE

  2. 2. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development

    University dissertation from Göteborgs universitet

    Author : Emma Danelius; Göteborgs universitet.; Gothenburg University.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; cyclic peptides; NMR; solution conformational analysis; NAMFIS; β-hairpin; weak interactions; halogen bonding; protein-protein interaction; bioactive conformation; macrolides; cell permeable conformation.;

    Abstract : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. READ MORE

  3. 3. Group A Streptococci; Epidemiology and Genetics of Antibiotic Resistance

    University dissertation from Department of Medical Microbiology, Lund University

    Author : Aftab Jasir; Lunds universitet.; Lund University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; typing; epidemiology; M protein; emm gene; erythromycin; tetracycline; macrolides; streptococci; antibiotics; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology;

    Abstract : Popular Abstract in Swedish Grupp A streptokocker (GAS) ger upphov till infektioner lokaliserade till svalg och hud såsom akut pharyngotonsillit (halsfluss), impetigo (svinkoppor), erysipelas (rosfeber) men även till invasiva (djupa) infektioner med allvarlig prognos, speciellt scarlatina (scharlakansfeber), puerperalfeber (barnsängsfeber), nekrotiserande fasciit och andra mjukdelsinfektioner samt sepsis (blodförgiftning). Ett s. READ MORE

  4. 4. Characterization of resistance to quinolones, sulfonamide and trimethoprim in Campylobacter jejuni as well as to macrolides in the related bacterium, Helicobacter pylori

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Amera Gibreel; Uppsala universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

    Abstract : Gastroenteritis caused by C. jejuni is usually a mild to moderate self-limiting disease. Treatment is recommended in some cases. In recent years, quinolones have been increasingly used to treat acute bacterial enteritis. READ MORE

  5. 5. Resistant pneumococci and use of antibiotics

    University dissertation from Department of Community Medicine, Malmö University Hospital

    Author : Eva Melander; Lunds universitet.; Lund University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; Mikrobiologi; mycology; virology; streptococcus pneumoniae; Antibiotics; drug resistance; bacteriology; Microbiology; virologi; mykologi;

    Abstract : Popular Abstract in Swedish Antibiotikaresistens hos pneumokocker har utvecklats till ett problem i hela världen. Interkontinental spridning av ett fåtal resistenta kloner verkar stå för den snabba ökningen av förekomsten av pneumokocker med nedsatt känslighet för penicillin (PNSP). READ MORE