Search for dissertations about: "macrophages microglia"

Showing result 1 - 5 of 41 swedish dissertations containing the words macrophages microglia.

2. 1. WNT signaling in microglia : WNTs as novel regulators of microglia

   Author : Carina Halleskog; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Microglia, the immunocompetent cells of the central nervous system (CNS) and the brain’s own macrophages are the most motile cells in the CNS and those with highest plasticity, as they rapidly move their projections to actively screen their environment for any type of injury. Upon cell damage or infection, microglia respond quickly: they proliferate, change morphology from ramified to amoeboid state to migrate or invade towards the injury, secrete many types of cytokines and chemokines to communicate with other inflammatory cells, and phagocytose cell debris. READ MORE

4. 2. Inflammatory response in the immature brainafter hypoxia-ischemia. Application of microarray and transgenic technology

   Author : Maj Hedtjärn; Göteborgs universitet; []
   Keywords : hypoxia-ischemia; neonatal; brain; inflammation; cytokine; IL-1; IL-18; microglia; ; gene; microarray;

   Abstract : Hypoxic-ischemic (HI) brain injury remains a common problem encountered during theneonatal period, and it is a major cause of perinatal mortality and long term neurologicalimpairments. After HI, an inflammatory reaction is elicited in the brain, which is believedto contribute to the secondary progression of brain injury. READ MORE

5. 3. Microglial cells in Neurodegenerative Diseases. The Role of Galectin-3

   Author : Antonio Boza Serrano; Neuroinflammation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurosciences; microglia; Galectin-3; Alzheimer disease; Parkinson disease; innate immune system; TLR4; TREM2;

   Abstract : Today, dementia such as, Alzheimer’s disease (AD), vascular diseases and motor neurodegenerative diseases, such as Parkinson’s disease (PD), represent a major public health problem. For instance, PD affect to more than 10 million people worldwide and almost 50 million people are affected by dementia. READ MORE

6. 4. Tumor-associated macrophages and microglia : double-edged sword in tumor evolvement and invasion

   Author : Tatjana Wallmann; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Tumor-associated macrophages (TAMs) are among the most abundant cell types in the tumor microenvironment. TAM infiltration is usually linked to tumor progression, metastasis and poor clinical outcome in most human cancers. READ MORE

7. 5. Macrophages : as central inflammatory mediators and as targets for therapeutic interventions

   Author : Åsa Andersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Macrophages; HMGB1; IL-23; MS; EAE; autoimmunity.;

   Abstract : Macrophages (Mphis) are important cellular players in autoimmune pathogenesis, being the most numerous cells infiltrating sites of inflammation and causing much of the associated tissue damage. Apart from these proinflammatory actions, Mphis also have distinct roles in disease resolution, and effective therapeutic targeting of Mphi-expressed molecules requires understanding of the interplay between different Mphi activators and the kinetics of the induced responses. READ MORE