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Showing result 1 - 5 of 18 swedish dissertations matching the above criteria.

  2. 1. Contact allergens in p-tert-butylphenol-formaldehyde resin

    Author : Erik Zimerson; Yrkes- och miljödermatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatology; main allergens; structure-activity relationships; identification of contact allergens; guinea pig maximization test; p-tert-butylphenol-formaldehyde resin; patch testing; venereology; Dermatologi; venereologi;

    Abstract : p-tert-Butylphenol-formaldehyde resin (PTBP-F-R) is used as a binder in many adhesive formulations and it consists of a complex mixture of substances, most of which are unknown. The resin has been reported to cause allergic contact dermatitis since the 1950s. READ MORE

  4. 2. Novel Computational Analyses of Allergens for Improved Allergenicity Risk Assessment and Characterization of IgE Reactivity Relationships

    Author : Daniel Soeria-Atmadja; Ulf Hammerling; Mats Gustafsson; Rob Aalberse; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergens; bioinformatics; statistical learning; performance estimation; risk assessment; Medical informatics; Medicinsk informatik;

    Abstract : Immunoglobulin E (IgE) mediated allergy is a major and seemingly increasing health problem in the Western countries. The combined usage of databases of molecular and clinical information on allergens (allergenic proteins) as well as new experimental platforms capable of generating huge amounts of allergy-related data from a single blood test holds great potential to enhance our knowledge of this complex disease. READ MORE

  5. 3. Analytical methodologies for common skin allergens : Organic thioureas, isothiocyanates and fragrance hydroperoxides in everyday life products

    Author : Ahmed Gamal Ramzi; Ulrika Nilsson; Anneli Julander; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical analysis; contact allergy; chloroprene rubber; diethyl thiourea; ethyl isothiocyanate; fragrance hydroperoxides; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes analytical methodologies for the determination of important skin-sensitizing chemicals in two types of commercial items: chloroprene rubber and fragrance products which are both well-known to be associated with contact allergy.Chloroprene rubber (neoprene) is widely used in different applications and products, such as bags, gloves, wetsuits, braces, mouse pads et c. READ MORE

  6. 4. Clinical and experimental studies on oxidized fragrance terpenes as contact allergens

    Author : Johanna Bråred Christensson; Göteborgs universitet; []
    Keywords : autoxidation; contact allergy; limonene; linalool; colophonium; limonene-1-hydroperoxide; limonene-2-hydroperoxide; 15-hydroperoxyabietic acid; 15-HPA; terpenes; local lymph node assay; LLNA; Freunds complete adjuvant test; FCAT; patch testing; laser Doppler imaging; skin irritation; visual reading;

    Abstract : The work presented in this thesis aims to improve the possibilities for diagnosing contact allergy to oxidized limonene and linalool and to, in patients, study contact allergy from structurally closely related hydroperoxides with regard to their specificity, potency and cross-reactivity. The fragrance terpenes limonene (from citrus oil) and linalool (from lavender oil) are widely used in household and industrial products. READ MORE

  7. 5. Allergy to laboratory animals : risk factors for development of allergy and methods for measuring airborne rodent allergens

    Author : Anne Renström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : laboratory animal allergy; atopy; IgE; methacholine provocation; aeroallergen measurement; ELISA; monoclonal antibody; Mus m 1; Rat n 1;

    Abstract : Between 10-50% of workers exposed to laboratory animals, mainly rats or mice, develop laboratory animal allergy (LAA) with symptoms of rhinitis, conjuctivitis, asthma, or urticaria, and IgE against animal allergens. Symptoms often arise within the first years of animal work. Up to half of the symptomatic subjects develop asthma. READ MORE