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Showing result 1 - 5 of 41 swedish dissertations matching the above criteria.

  2. 1. Novel immunization strategies and interethnic differences in response to malaria infection

    Author : Charles Arama; Marita Troye-Blomberg; Kai Matuschewski; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Malaria; Immunization; Ethnic groups; vaccines; immunologi; Immunology;

    Abstract : A better understanding of the role of antigen-presenting cells (APCs) in host resistance to malaria is essential to unravel the complex interactions between the host and the parasite. This would improve the design of malaria vaccines. READ MORE

  4. 2. Vaccine development strategies applied to the Plasmodium falciparum malaria antigen 332

    Author : Nina-Maria Vasconcelos; Klavs Berzins; Matti Sällberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; malaria; sub-unit vaccines; immunogenicity; antibody response; antigen Pf332; Immunology; Immunologi;

    Abstract : Malaria is one of the major infectious diseases in the world with regard to mortality and morbidity, and the development of a vaccine against the malaria parasite Plasmodium falciparum is considered of high priority. The aim of the work presented in this thesis was to develop and characterize recombinant vaccine constructs based on the P. READ MORE

  5. 3. Immune Regulation During Malaria Infection

    Author : Helena Helmby; Edvard Pearce; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : Malaria is the largest parasitic disease in the world and is caused by the protozoon Plasmodium. The most severe form in humans is caused by Plasmodium falciparum. Immunity to malaria involves both cell-mediated and humoral responses and develops slowly over a period of ten to fifteen years, requiring repeated infections. READ MORE

  6. 4. Malaria during pregnancy and childhood : A focus on soluble mediators and neutrophils

    Author : Stéphanie Boström; Marita Troye-Blomberg; Maria Yazdanbakhsh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plasmodium falciparum; pregnancy; childhood; neutrophils; biomarkers; cytokines; chemokines; antibodies; Fulani; Dogon; immunologi; Immunology;

    Abstract : In areas where malaria is endemic, pregnant women and children bear the main burden of severe and life-threatening malarial disease. The aim of this work was to study the impact of Plasmodium falciparum infection on inflammatory responses in pregnant women and children residing in African countries. READ MORE

  7. 5. Human genetic factors involved in immunity to Plasmodium falciparum infection

    Author : Manijeh Vafa Homann; Marita Troye-Blomberg; Marcel Hommel; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plasmodium falciparum; Malaria; Immunity; Ethnic groups; Mali; Senegal; Genetic factors; IL-4; IL-10; Polymorphism; MOI; RBC variants; Immunology; Immunologi; immunologi; Immunology;

    Abstract : This study investigated the associations between IL-4 -590 C/T and IL-10 -1087 A/G polymorphisms and malariometric indexes in the Fulani and the Dogon ethnic groups living in sympatry in Mali and differing in susceptibility to malaria. The correlations between antibodies level and parasitological data as well as splenomegaly were assessed. READ MORE