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Showing result 1 - 5 of 29 swedish dissertations matching the above criteria.

  2. 1. Determination of biomarkers for lipid peroxidation and oxidative stress : Development of analytical techniques and methods

    Author : Kristina Claeson Bohnstedt; Bo Karlberg; Niels Heegaard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; capillary electrophoresis; mass spectrometry; electrospray; porous graphitic carbon; oxidative stress; lipid peroxidation; biomarker; malondialdehyde; hydroxynonenal; isoprostane; Analytical chemistry; Analytisk kemi;

    Abstract : Oxidative stress can be defined as a state of disturbance in the pro-oxidant/antioxidant balance in favour of the former, leading to potential damage. Processes associated with oxidative stress involve reactive oxygen species and radicals and can result in elevated levels of oxidatively modified or toxic molecules that can cause cellular malfunction, and even cell death. READ MORE

  4. 2. Exhaled markers of oxidative stress in the airways

    Author : Mona Lärstad; Göteborgs universitet; []
    Keywords : exhaled air; exhaled breath condensate; malondialdehyde; 3-nitrotyrosine; ethane; pentane; isoprene; oxidative stress; airways; inflammation;

    Abstract : Breath contains a number of different molecules, some of which may have potential use as markers for oxidative stress in the airways during chronic airway inflammation. The major objectives were to develop and validate methods for quantifying five potential exhaled markers of oxidative stress: malondialdehyde (MDA) and free 3-nitrotyrosine (3-NT) in exhaled breath condensate (EBC) and ethane, pentane and isoprene in exhaled air, and to test the applicability of the methods. READ MORE

  5. 3. Nitrates and Left Ventricular Dysfunction

    Author : Erik Tingberg; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid peroxidation; malondialdehyde; peptide; brain natriuretic peptide; left ventricular dysfunction; nitrates; acute myocardial infarction; heart failure; atrial natriuretic; diuretics; echocardiography; haemodynamic measurements; neurohumoral activation; diastolic dysfunction; Cardiovascular system; Medicin människa och djur ; Medicine human and vertebrates ; Kardiovaskulära systemet; oxidative stress; isoprostanes;

    Abstract : Use of beta-blockers and inhibitors of the renin angiotensin system (RAS) is established practice in the treatment of chronic heart failure (CHF). Clinical studies also suggest beneficial long-term effects of nitrates in CHF. READ MORE

  6. 4. Cellular immunity and inflammation in atherosclerosis

    Author : Dirk Marcus Wuttge; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; T cell; oxLDL; malondialdehyde; hapten; posttranslational; interleukin-] 5; retinoic acid receptor; inflammation;

    Abstract : Atherosclerosis, the major cause of death and disability in western countries, is nowadays recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the subendothelial space, where compounds inside of LDL are chemically modified through lipid peroxidation. READ MORE

  7. 5. Micellar electrokinetic chromatography with laser-induced fluorescence detection applied to the analysis of biological samples

    Author : Gunnar Thorsén; Andrew G Ewing; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical Chemistry; analytisk kemi;

    Abstract : The research presented in this thesis is focused on the potential for using the combination of micellar electrokinetic chromatography with laser-induced fluorescence detection for the determination of compounds in biological samples. The topics that have been addressed are the development of separation electrolytes, the need for sample preparation procedures, the derivatization of the compounds of interest and the detection of these by laser-induced fluorescence. READ MORE