Search for dissertations about: "mao-b"
Showing result 1 - 5 of 13 swedish dissertations containing the word mao-b.
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1. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice
Abstract : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. READ MORE
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2. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies
Abstract : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. READ MORE
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3. Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)
Abstract : Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the treatment of psychiatric and neurological disorders. READ MORE
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4. Attention-deficit/hyperactivity disorder and disruptive behavior disorders in adolescence related to levels of platelet MAO-B and polymorphisms in two candidate genes
Abstract : Background: Attention-Deficit/Hyperactivity Disorder (ADHD) and Disruptive Behavior Disorders (DBD) (including Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD)), are common developmental and behaviour diagnoses among adolescents. Several of their symptoms, have been linked to genotypes (e.g. READ MORE
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5. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects
Abstract : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. READ MORE