Search for dissertations about: "maob"

Showing result 1 - 5 of 8 swedish dissertations containing the word maob.

  2. 1. Maf transcription factors in beta cell function

    Author : Elvira Ganic; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE

  4. 2. Genetic studies of depressive symptoms

    Author : Mårten Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Depressive Symptoms; Twin; Heritability; Serotonin receptor 2A; Serotonin transporter; MAOA; MAOB; Thrombocyte MAO activity; Linkage Disequilibrium.;

    Abstract : This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. READ MORE

  5. 3. The Relation between Serotonergic Biomarkers and Behaviour : – studies on human primates, non-human primates and transgenic mice

    Author : Hanna-Linn Wargelius; Dan Larhammar; Lars Oreland; Claudia Fahlke; Elias Eriksson; Uppsala universitet; []
    Keywords : Serotonin; MAO-A; 5-HTT; MAO-B; alcohol; ADHD; MEDICINE; MEDICIN; Medicin; Medicine; Neuroscience; Neurovetenskap;

    Abstract : Rationale: The serotonergic system is involved in the modulation of emotion and plays an important role for personality and vulnerability for psychiatric disorders. In the papers included in this thesis, we investigate three biological factors that have been studied in relation to psychiatric symptoms: Platelet monoamine oxidase B (MAO-B) activity, and variations in the MAO-A and the serotonin transporter (5HTT) genes. READ MORE

  6. 4. Genetic studies of two inherited human phenotypes : Hearing loss and monoamine oxidase activity

    Author : Jorune Balciuniene; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; linkage analysis; hearing loss; digenic inheritance; allelic association; monoamine oxidase; human genetic diversity; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : This thesis focuses on the identification of genetic factors underlying two inherited human phenotypes: hearing loss and monoamine oxidase activity. Non-syndromic hearing loss segregating in a Swedish family was tested for linkage to 13 previously reported candidate loci for hearing disabilities. READ MORE

  7. 5. Comparative sequencing of candidate genes in complex disease

    Author : Shane McCarthy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA; Sequencing; Complex Disease; Candidate Gene;

    Abstract : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. READ MORE