Search for dissertations about: "mass spectrometry - LC-MS MS"

Showing result 16 - 20 of 122 swedish dissertations containing the words mass spectrometry - LC-MS MS.

2. 16. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

   Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

   Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE

4. 17. Mass-spectrometry based survey of BMAA sources, distribution and transfer

   Author : Nadezda Zguna; Leopold Ilag; Jonas Bergquist; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; BMAA; LC-MS MS; chiral analysis; seafood; toxins; Baltic Sea; derivatization; Analytical Chemistry; analytisk kemi;

   Abstract : β-methylaminoalanine (BMAA) is a neurotoxic non-protein amino acid first isolated from cycad seeds in 1967. It is believed to be connected to neurodegenerative diseases such as Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS) and is a ubiquitous compound produced by cyanobacteria, diatoms and dinoflagellates. READ MORE

5. 18. Quality Control for high-throughput Quantitative Proteomics - Harnessing the potential of label-free LC-MS

   Author : Marianne Sandin; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; mass spectrometry; quality control; data analysis; label-free; feature detection; alignment; biomarker discovery; separation techniques;

   Abstract : Multiplex protein quantification, proteomics, is essential for uncovering new biomarkers and understanding biology. Liquid chromatography coupled to mass spectrometry (LC-MS) is the predominant technique for these measurements. READ MORE

6. 19. Statistical and machine learning methods to analyze large-scale mass spectrometry data

   Author : Matthew The; Lukas Käll; Oliver Kohlbacher; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry - LC-MS MS; statistical analysis; data processing and analysis; protein inference; large-scale studies; simulation; protein quantification; clustering; machine learning; Bayesian statistics; Bioteknologi; Biotechnology;

   Abstract : Modern biology is faced with vast amounts of data that contain valuable information yet to be extracted. Proteomics, the study of proteins, has repositories with thousands of mass spectrometry experiments. These data gold mines could further our knowledge of proteins as the main actors in cell processes and signaling. READ MORE

7. 20. Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome

   Author : Masoumeh Karimpour; Malin Nording L.; Magnus Åberg; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LC MS; GC MS; NMR; metabolomics; metabolite; exposure; postprandial; plasma; lung lavage; BW; BW; data analysis; univariate analysis; multivariate analysis;

   Abstract : Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). READ MORE