Search for dissertations about: "mass spectrometry"

Showing result 1 - 5 of 1107 swedish dissertations containing the words mass spectrometry.

  2. 1. Improved Neuropeptide Identification : Bioinformatics and Mass Spectrometry

    Author : Maria Fälth Savitski; Per Andrén; David Fenyö; Per Svenningsson; Ronald Beavis; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; neuropepides; database; peptide identification; peptide fragmentation; mass spectrometry; tandem mass spectromerty; Bioinformatics; Bioinformatik;

    Abstract : Bioinformatic methods were developed for improved identification of endogenous peptides using mass spectrometry. As a framework for these methods, a database for endogenous peptides, SwePep, was created. It was designed for storing information about endogenous peptides including tandem mass spectra. READ MORE

  4. 2. Mass Spectrometry-based Neuroproteomics : Deciphering the Human Brain Proteome

    Author : Sravani Musunuri; Jonas Bergquist; Ganna Shevchenko; Jean-Charles Sanchez; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Brain; Proteomics; Mass spectrometry; Alzheimer s disease; Traumatic brain injury; Membrane proteins; Sample preparation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. READ MORE

  5. 3. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Author : Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. READ MORE

  6. 4. Precision mass measurements : Final limit of SMILETRAP I and the developments of SMILETRAP II

    Author : Andreas Solders; Reinhold Schuch; Juha Äystö; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; SMILETRAP; Precision mass spectrometry; Penning trap; Atomic mass; Highly charged ions; Low energy ion storage; Time of flight ion cyclotron resonance; High frequency; Proton mass; QED; g-factor; Physics; Fysik; Physics; fysik;

    Abstract : The subject of this thesis is high-precision mass-measurements performed with Penning trap mass spectrometers (PTMS). In particular it describes the SMILETRAP I PTMS and the final results obtained with it, the masses of 40Ca and that of the proton. READ MORE

  7. 5. Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications

    Author : My Moberg; Jonas Bergquist; Karin E. Markides; Dan Bylund; Douglas B. Kell; Uppsala universitet; []
    Keywords : Analytical chemistry; liquid chromatography; mass spectrometry; tandem mass spectrometry; electrospray ionization; inductively coupled plasma; chemometrics; optimization; multivariate data analysis; design of experiments; response surface model; siderophore; azathioprine; peptide; Analytisk kemi;

    Abstract : Liquid chromatography (LC) coupled to mass spectrometry (MS) offers highly selective and sensitive analysis of a wide variety of compounds. However, the use of hyphenated experimental set-ups implies that many parameters may have an effect on the studied response. READ MORE