Search for dissertations about: "massively parallel sequencing"
Showing result 6 - 10 of 36 swedish dissertations containing the words massively parallel sequencing.
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6. Enabling massive genomic and transcriptomic analysis
Abstract : In recent years there have been tremendous advances in our ability to rapidly and cost-effectively sequence DNA. This has revolutionized the fields of genetics and biology, leading to a deeper understanding of the molecular events in life processes. READ MORE
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7. Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas
Abstract : .... READ MORE
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8. Hereditary Colorectal Cancer; Identification, Characterization and Classification of Mutations
Abstract : Hereditary factors are thought to play are role in 20-30% of all colorectal cancers Around 6% are found as high penetrant disease-causing mutations in genes correlated to hereditary polyposis or hereditary non-polyposis syndromes. The aim of this thesis was to identify new causative genes and variants and also mutation mechanisms in families presenting a polyposis, atypical polyposis or nonpolyposis CRC phenotype. READ MORE
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9. Mitochondrial Genome Analysis Using Next Generation Sequencing for Forensic Applications
Abstract : Mitochondrial DNA (mtDNA) analysis plays a specialized role in forensic applications, overcoming certain limitations of autosomal DNA markers. The high copy number and uniparental inheritance pattern of mtDNA are advantageous in cases involving shed hairs and aged skeletal elements, especially decades-old missing persons cases. READ MORE
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10. Next Generation Sequencing for Measurable Residual Disease Detection in Acute Myeloid Leukemia
Abstract : Acute myeloid leukemia (AML) is the most common form of acute leukemia and generally associated with a poor prognosis. For both children and adults, the treatment is based on chemotherapy. Allogeneic hematopoietic stem cell transplant (alloHCT) is reserved for patients with intermediate or high risk of relapse, due to its associated risks. READ MORE