Search for dissertations about: "matricellular protein"

Found 3 swedish dissertations containing the words matricellular protein.

  2. 1. Studies of anemia in the myelodysplastic syndromes

    Author : Martin Jädersten; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myelodysplasia; growth factors; Cox regression; delayed entry; left truncation; mortality; international prognostic scoring system; IPSS; who-classification based prognostic scoring system; WPSS; thalidomide analogue; IMiD; hematopoietic stem cell; adhesion; stroma; matrix; osteonectin; matricellular protein; NPM1; immunohistochemistry.;

    Abstract : Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). The first line therapy of anemia in MDS is erythropoietin (EPO) with or without granulocyte colony-stimulating factor (G-CSF). READ MORE

  4. 2. Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility

    Author : Anna Forslöw; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human immune system, which protects the body from invading pathogens, largely depends on the proper function of lymphocytes, which are highly motile and constantly recirculate the blood and lymph. Adhesive and motile capability is often amplified or uncontrolled during chronic inflammatory conditions such as autoimmune diseases. READ MORE

  5. 3. Molecular and cellular characterization of midbrain dopaminergic neuron development

    Author : Daniel Gyllborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. READ MORE