Search for dissertations about: "matrix metalloproteases"
Showing result 1 - 5 of 11 swedish dissertations containing the words matrix metalloproteases.
-
1. Matrix metalloproteases and cell motility in malignant mesothelioma
Abstract : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. READ MORE
-
2. The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer
Abstract : Breast cancer is the most common cancer among women worldwide today. Nearly 9000 women are diagnosed with breast cancer in Sweden yearly and despite advantages in diagnostics and treatments approximately 1400 women still die from their disease every year. READ MORE
-
3. Matrix degrading proteases in the ovary : expression and function
Abstract : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. READ MORE
-
4. Studies of cell migration and matrix protease production in human lung cancer cell lines
Abstract : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. READ MORE
-
5. The importance of astroglial cells in ischemia, regeneration and angiogenesis
Abstract : Astrocytes in the CNS communicate with both neurons and blood vessels. In many CNS pathologies, astrocytes respond by becoming reactive. Whether their performance at this stage is beneficial or detrimental for CNS function is unclear. READ MORE