Search for dissertations about: "matrix-metalloprotease"
Showing result 1 - 5 of 6 swedish dissertations containing the word matrix-metalloprotease.
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1. The importance of astroglial cells in ischemia, regeneration and angiogenesis
Abstract : Astrocytes in the CNS communicate with both neurons and blood vessels. In many CNS pathologies, astrocytes respond by becoming reactive. Whether their performance at this stage is beneficial or detrimental for CNS function is unclear. READ MORE
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2. Aggrecan fragments as biomarkers in osteoarthritis
Abstract : Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. READ MORE
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3. Aspects of the glomerular barrier in healthy and diabetic kidneys
Abstract : Each day 180 liters of plasma is filtered in the kidneys. Under normal conditions, the glomerular barrier restricts the passage of macromolecules such as albumin while it is highly permeable to water and small solutes. Proteinuria is a hallmark of renal disease and reflects impairment of the glomerular barrier. READ MORE
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4. Female stress incontinence and uterovaginal prolapse : collagen turnover and hormone sensitivity in urogenital tissue
Abstract : Background: Prevalence of both stress urinary incontinence (SUI) and uterovaginal prolapse (UP) is high and rising with age. Risk factors include multiparity, obesity, chronic obstructive lung disease and previous gynecological surgery. The underlying pathology is still unknown but may include defective connective tissue. READ MORE
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5. Bacteria-based methods for engineering and characterization of proteases and affinity proteins
Abstract : This thesis is focused on the development of methods for characterization and engineering of both proteases and affinity proteins. In addition, a prodrug concept for small affinity proteins is developed.Two of the developed methods are for engineering and/or characterization of proteases. READ MORE