Search for dissertations about: "mdm"

Showing result 1 - 5 of 10 swedish dissertations containing the word mdm.

  2. 1. Sarcoma of the female genital tract : Histopathology, DNA cytometry, p53 and mdm-2 analysis related to prognosis

    Author : René Blom; Ernst Simonsen; Henric Malmström; Olle Stål; Anders Jakobsen; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sarcoma; female genital tract; tumors; MMMT; Oncology; Onkologi;

    Abstract : Sarcomas of the female genital tract are rare tumors and account for less than 5% of gynecologic malignancies. Traditionally, gynecologic sarcomas have been divided into different tumor types according to their histopathological features. READ MORE

  4. 2. Prognostic markers in breast cancer associated with cell cycle control, proliferation and angiogenesis

    Author : Thomas Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; TP53; VEGF; cyclin E; Ki-67; MIB-1; p21; MDM-2; survival; prognostic markers;

    Abstract : This thesis focuses on potential prognostic molecular breast cancer markers which are related to angiogenesis, proliferation or cell cycle control. A common denominator for all of the investigated markers in the thesis is either hypothesized or previously reported association with the tumor suppressor gene TP53. READ MORE

  5. 3. Inflammation and Stem Cell Therapy for Stroke

    Author : Ruimin Ge; Lund Neurologi; []
    Keywords : ;

    Abstract : Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. READ MORE

  6. 4. Growth factor pathways in human cancer : functional and therapeutic implications

    Author : Leonard Girnita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF-1R; growth factors; p53; fusion protein; tyrosine kinase inhibitors; ubiquitin;

    Abstract : The multi-step development of tumors involves numerous changes at genomic level such as oncogene activation, loss of function of tumor suppressor genes and translocations resulting in fusion genes that encodes for chimeric proteins with tumorigenic functions etc. However, in the selection leading to cancer in somatic tissues it is likely that the cancer cells make use of the normal extracellular signaling for proliferation and/or anti-apoptosis to create growth advantage over the normal cells. READ MORE

  7. 5. A Model Management and Integration Platform for Mechatronics Product Development

    Author : Jad El-Khoury; Martin Törngren; Holger Giese; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Engineering mechanics; Teknisk mekanik;

    Abstract : Mechatronics development requires the close collaboration of various specialist teams and engineering disciplines. Developers from the different disciplines use domain-specific tools to specify and analyse the system of interest. READ MORE