Search for dissertations about: "mechanism of glucocorticoid action"

Showing result 1 - 5 of 11 swedish dissertations containing the words mechanism of glucocorticoid action.

  1. 1. Functional analysis of ligand recognition by the glucocorticoid receptor

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Nutrition

    Author : Ulrika Lind; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; steroid-binding; site-directed mutagenesis; protein-ligand interaction; mechanism of glucocorticoid action;

    Abstract : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. READ MORE

  2. 2. Studies on the therapeutic modulation of inflammation in the synovial membrane of rheumatoid arthritis

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Solna

    Author : Petra Neregård; Karolinska Institutet.; Karolinska Institutet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane that can lead to joint deformity and physical disability. Despite recent progress in the therapeutic field of RA, the exact molecular mechanisms responsible for chronic joint inflammation are not yet completely understood. READ MORE

  3. 3. Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Thomas Meyer; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; osteocalcin; gene regulation; TATA box element;

    Abstract : Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. READ MORE

  4. 4. Repression of transcription factor NF-[kappa]B by glucocorticoids : a molecular mechanism for their anti-inflammatory and immuno-modulatory effects

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Nutrition

    Author : Johan Lidén; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : It has been known since the late 1940s that glucocorticoids (GCs) possess anti-inlammatory activity. Their various uses in the clinic include treatment of, rheumatoid arthritis, asthma and AIM skin diseases and also as means for avoiding rejection during transplantation. READ MORE

  5. 5. New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda Rickardson; Uppsala universitet.; [2008]
    Keywords : Pharmacology; Cancer drugs; Screening; Gene expression; Farmakologi;

    Abstract : Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. READ MORE