Search for dissertations about: "mechanism of tissue repair"

Showing result 1 - 5 of 43 swedish dissertations containing the words mechanism of tissue repair.

  2. 1. Tumors associated with Hereditary Nonpolyposis Colorectal Cancer: Defective Mismatch Repair and Familial Risk of Cancer

    Author : Kajsa Ericson Lindquist; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; cancerology; Cytologi; onkologi; cancer; Multiple Tumors; Hereditary Nonpolyposis Colorectal Cancer; Cytology; Cohort study; Population based; Familial Risk of Cancer; Immunohistochemistry; MSH2; MSH6; MLH1; Microsatellite Instability; Soft Tissue Sarcomas; Cancer of the Upper Urinary Tract; Cancer of the Small Intestine; Colorectal Cancer;

    Abstract : Inactivation of the DNA mismatch repair (MMR) system is a tumorigenic mechanism involved in 15-20% of tumor types such as colorectal and endometrial cancer and is specifically associated with the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome. These MMR defective tumors are characterized by microsatellite instability (MSI), a phenomenon that reflects alterations in length of repeated sequences, and 90% of MSI tumors show loss of immunohistochemical expression for the MMR protein affected. READ MORE

  4. 2. Mechanisms and improvements of cell transplantation for nerve repair

    Author : Kai-Hei Tse; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stem cells; microporous scaffold; biomaterials; ischemia; cell death; brain derived neurotrophic factor;

    Abstract : Trauma to the nervous system is a frequent clinical problem and new approaches to nerve repair are required. Autologous cell transplantation together with a suitable scaffold material could be used to create a bio-active artificial nerve graft to enhance regeneration. READ MORE

  5. 3. Atherosclerotic Plaque Stability and Vascular Repair

    Author : Anki Knutsson; Kärlväggsbiologi; []
    Keywords : atherosclerosis; diabetes; repair; inflammation; extracellular matrix;

    Abstract : Myocardial infarction and stroke are two of the most common causes of death in the world, mainly caused by a rupture of an atherosclerotic plaque. A vulnerable atherosclerotic plaque is a high-risk plaque that can form a thrombus by rupture. READ MORE

  6. 4. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue

    Author : Juan Sebastián Yakisich; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA replication - Cell cycle - Brain - Gliomas - Tissue mini-unit - Protein kinases - Proteases Inhibitors - Roscovitine;

    Abstract : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. READ MORE

  7. 5. The role of TPPII in apoptosis control and treatment of malignant disease

    Author : Hong Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : proteasome; tripeptidyl peptidase II; apoptosis; inhibitor of apoptosis LAP ; p53; Phosphoinositid-30H-kinase-related-kinases PIKK ;

    Abstract : Degradation of cytosolic proteins depends largely on the proteasome. This complex contains a catalytic core (20S) and an accessory complex (19S) that recognizes ubiquitinated substrates and translocates these to the catalytic sites in the 20S particle. READ MORE