Search for dissertations about: "mechanistic study"

Showing result 1 - 5 of 278 swedish dissertations containing the words mechanistic study.

  1. 1. Cannabinoids as neuroprotective agents a mechanistic study

    University dissertation from Umeå : Farmakologi och klinisk neurovetenskap

    Author : Olov Nilsson; Christopher Fowler; Edward Högestätt; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cannabinoid; neuroprotection; inflammation; cytokine; neutrophil; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi;

    Abstract : Glucose and oxygen supply to the brain is critical for its proper function and when it is restricted as during a stroke, neurons and glial cells quickly become necrotic leading to structural damage as well as functional impairment and even death. To date there are few effective therapies that inhibit the neurodegenerative process and improves the outcome for the affected individual. READ MORE

  2. 2. Transition metal-catalyzed allylic and vinylic functionalization Method development and mechanistic investigations

    University dissertation from Stockholm : Department of Organic Chemistry, Stockholm Univeristy

    Author : Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; Organic Chemistry; organisk kemi;

    Abstract : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. READ MORE

  3. 3. Oxidative dissolution of doped UO2 and H2O2 reactivity towards oxide surfaces A kinetic and mechanistic study

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Kristina Nilsson; Mats Jonsson; Mats Johansson; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative dissolution; UO2; ADOPT; H2O2; Spent Nuclear Fuel.; Kemi; Chemistry;

    Abstract : Oxidative dissolution of std. UO2 and UO2 doped with Cr2O3 and Al2O3, i.e. ADOPT, induced by H2O2 and γ radiation has been the main focus in this licentiate thesis. READ MORE

  4. 4. Asymmetric transfer hydrogenation of ketones Catalyst development and mechanistic investigation

    University dissertation from Stockholm : Department of Organic Chemistry, Stockholm University

    Author : Katrin Ahlford; Hans Adolfsson; Martin Wills; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; reduction; amino acid; rhodium; mechanistic investigation; kinetic study; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; Organic Chemistry; organisk kemi;

    Abstract : The development of ligands derived from natural amino acids for asymmetric transfer hydrogenation (ATH) of prochiral ketones is described herein. In the first part, reductions performed in alcoholic media are examined, where it is found that amino acid-derived hydroxamic acids and thioamides, respectively, are simple and versatile ligands that in combination with [RhCp*Cl2]2 efficiently catalyze this particular transformation. READ MORE

  5. 5. Pea carbonic anhydrase a kinetic study

    University dissertation from Stockholm : Department of Organic Chemistry, Stockholm University

    Author : Inga-Maj Johansson; W. Richard Chegwidden; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pisum sativum; carbonic anhydrase; kinetic studies; site-directed mutagenisis;

    Abstract : The enzyme carbonic anhydrase (CA), catalysing the interconversion between CO2 and HCO3', has long been known to be present in plants as well as in animals. Several of the animal isozymes, but none of the plant CAs, have been extensively studied. READ MORE