Search for dissertations about: "mechanistic study"
Showing result 21 - 25 of 388 swedish dissertations containing the words mechanistic study.
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21. Re-evaluation of exercise-induced muscle soreness : an immunohistochemical and ultrastructural study
Abstract : Delayed onset muscle soreness (DOMS) is a familiar experience for the elite and novice athletes. Symptoms can range from muscle tenderness to severe deliberating pain. It is generally believed that eccentric contractions produce higher tension on muscle fibres and connective tissues than concentric and isometric contractions. READ MORE
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22. Asymmetric Transfer Hydrogenation of Aromatic Ketones : Catalyst Development and Mechanistic Studies
Abstract : This thesis describes the development and evaluation of new chiral Ru(arene)(amino alcohol) catalysts for the transfer hydrogenation of aromatic ketones using isopropanol as the hydrogen source. Two mechanistic studies of the Ru(arene)(amino alcohol) catalyzed transfer hydrogenation of acetophenone were also conducted. The Ru(arene)[(1S,3R,4R)-3. READ MORE
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23. Oxidative Trifluoromethylation and other Functionalization Reactions of Alkenes and Alkynes
Abstract : This thesis concerns the use of various potent oxidants in organic synthesis. The main focus is directed at selectively introducing trifluoromethyl groups into compounds containing double or triple bonds. All reactions proceed under mild conditions and can in most cases be performed on the bench-top. READ MORE
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24. Transition metal-catalyzed reduction of carbonyl compounds : Fe, Ru and Rh complexes as powerful hydride mediators
Abstract : A detailed mechanistic investigation of the previously reported ruthenium pseudo-dipeptide-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones was performed. It was found that the addition of alkali metals has a large influence on both the reaction rate and the selectivity, and that the rate of the reaction was substantially increased when THF was used as a co-solvent. READ MORE
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25. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE