Search for dissertations about: "medical ionizing radiation"

Showing result 6 - 10 of 75 swedish dissertations containing the words medical ionizing radiation.

  2. 6. Radiation response in human cells : DNA damage formation, repair and signaling

    Author : Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. READ MORE

  4. 7. Water–fat separation in magnetic resonance imaging and its application in studies of brown adipose tissue

    Author : Jonathan Andersson; Joel Kullberg; Håkan Ahlström; Mark Lubberink; Kerstin Lagerstrand; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; brown adipose tissue; magnetic resonance imaging; water–fat signal separation; graph-cut; positron emission tomography; 18F-fludeoxyglucose; infrared thermography; machine learning; artificial neural networks; deep learning; convolutional neural networks; Radiology; Radiologi;

    Abstract : Virtually all the magnetic resonance imaging (MRI) signal of a human originates from water and fat molecules. By utilizing the property chemical shift the signal can be separated, creating water- and fat-only images. READ MORE

  5. 8. Micro/nanometric Scale Study of Energy Deposition and its Impact on the Biological Response for Ionizing Radiation : Brachytherapy radionuclides, proton and carbon ion beams

    Author : Fernanda Villegas Navarro; Anders Ahnesjö; Carmen Villagrasa; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ionizing radiation; Monte Carlo track structure code; Microdosimetric spread; Energy deposition clustering; RBE; Medicinsk radiofysik; Medical Radiophysics;

    Abstract : Research in radiotherapy for cancer treatment focuses on finding methods that can improve the compromise between tumour cell inactivation versus damage to the surrounding healthy tissue. As new radiation modalities such as proton therapy become accessible for everyday clinical practice, a better understanding of the variation in biological response of the tumour and healthy tissues would improve treatment planning to achieve optimal outcome. READ MORE

  6. 9. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure

    Author : Nils Rudqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; iodine-131; radionuclide therapy; nuclear medicine; environmental exposure; thyroid; radiation biology; transcriptomics; proteomics; ionizing radiation; toxicity; normal tissue damage; microarray; LC-MS; biomarker;

    Abstract : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. READ MORE

  7. 10. Biomarker discovery and assessment for prediction of kidney response after 177Lu-octreotate therapy

    Author : Emil Schüler; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRRT; somatostatin; radionuclide therapy; 177Lu-octreotate; scintigraphy; renal function; toxicity; kidney response; radiation biology; microarray; molecular biomarkers; ionizing radiation; miRNA; proteomics; transcriptional response;

    Abstract : Patients suffering from neuroendocrine tumors are oftentimes presented with spread disease at the time of diagnosis. Therapy using somatostatin analogs is today the only potentially curative treatment option for these patients. READ MORE