Search for dissertations about: "medical thesis sample"

Showing result 21 - 25 of 1010 swedish dissertations containing the words medical thesis sample.

2. 21. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes

   Author : Xiang Jiao; Tobias Sjöblom; Anne-Lise Børresen-Dale; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; breast cancer; cancer gene; pathway; somatic mutation; structural alteration; sequencing; whole genome amplification; Genetics; Genetik; Medical Genetics; Medicinsk genetik;

   Abstract : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. READ MORE

4. 22. Fibroblast Differentiation and Models of Human Skin

   Author : Jonathan Rakar; Gunnar Kratz; Ingemar Rundquist; Anders Lindahl; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : This thesis combines three publications and one manuscript, covering two principal topics: functional differentiation of human fibroblasts and laboratory models of human skin. The two topics favourably unite in the realm of tissue engineering. This thesis is therefore split into three main parts: 1. READ MORE

5. 23. Genetic Cartography at Massively Parallel Scale

   Author : Johan Dahlberg; Ann-Christine Syvänen; Adam Ameur; Michael C. Zody; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia ALL ; RNA-Sequencing; Bioinformatics; Pooling; Whole Genome Sequencing; Medicinsk genetik; Medical Genetics; Bioinformatics; Bioinformatik;

   Abstract : Massively parallel sequencing (MPS) is revolutionizing genomics. In this work we use, refine, and develop new tools for the discipline.MPS has led to the discovery of multiple novel subtypes in Acute Lymphoblastic Leukemia (ALL). In Study I we screen for fusion genes in 134 pediatric ALL patients, including patients without an assigned subtype. READ MORE

6. 24. Genetic and environmental risk factors of cervical carcinoma in Situ

   Author : Agnetha Josefsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Cervical carcinoma; Human papillomavirus; exonuclease assay; persistence; viral copy number; quantitation; p53; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Invasive cervical cancer is the third most common cancer form among women. In 1990 there were approximately 370,000 new cases diagnosed in the world. The risk of morbidity and mortality of cervical cancer among women is a problem, particularly in the developing countries. READ MORE

7. 25. Utilization and allocation of organs for transplantation - medical and ethical aspects

   Author : Marie Omnell-Persson; Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; estetik; metafysik; kunskapsteori; ideologi; Immunology; serology; transplantation; Immunologi; serologi; ideology; epistemology; aesthetics; metaphysics; Systematic philosophy; ethics; utilization; organ donation; kidney transplantation; Allocation; attitudes; Praktisk filosofi;

   Abstract : Great efforts have been made to find solutions to the shortage of organs, such as extending the donor pool by accepting so-called marginal donors and development of transplantation of organs from animals (xenotransplantation, xt). Due to the scarcity of organs, there is a long tradition of prioritizing among patients on the waiting list for transplantation. READ MORE