Search for dissertations about: "medicinsk biokemi"

Showing result 6 - 10 of 428 swedish dissertations containing the words medicinsk biokemi.

  2. 6. Roles of Heparan Sulfate in Amyloid-β Pathology and Hypoxia

    Author : Elina Hjertström; Jin-ping Li; Ulf Lindahl; Sally Stringer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; Alzheimer s disease; Aβ; Proteoglycan; Heparanase; Amyloid; Hypoxia; Cancer; Spalax; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate (HS) is a highly sulfated polysaccharide expressed on the cell surface and in the extracellular matrix, interacting with a large number of proteins. HS is implicated in human diseases, including different types of cancer and amyloid diseases such as Alzheimer's disease (AD). READ MORE

  4. 7. The megalin receptor

    Author : Göran Hjälm; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium; parathyroid; gp330; megalin; LRP-2; LDL-receptor super family; endogenous retroviruse; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Ionized calcium is a major player in the living organism. Its importance in both intra- and extracellular mechanisms have been studied in a broad number of publications. READ MORE

  5. 8. Regulation of hyaluronan biosynthesis : Expression in vitro and importance for tumor progression

    Author : Annica Jacobson; Anders Hjerpe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Hyaluronan, a component of the extracellular matrix, is synthesized by either of three hyaluronan-synthesizing enzymes termed Has1, Has2 and Has3. The expression level of each Has gene varies between cell types of mesenchymal origin and is differentially regulated in response to external stimuli. READ MORE

  6. 9. Structure and functions of heparan sulfate/heparin – Importance of glucuronyl C5-epimerase and heparanase

    Author : Juan Jia; Jin-Ping Li; Ulf Lindahl; Hiroshi Nakato; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Heparan sulfate (HS) and heparin are linear polysaccharide chains covalently O-linked to serine residues within the core proteins, so called HS proteoglycans (PGs) or heparin PG. HSPGs are produced by almost all mammalian cells and known to play important roles in developmental processes, physiological and pathological conditions; whereas heparin PG is produced by mast cells and best known as an anticoagulant in clinic. READ MORE

  7. 10. The Role of Microvascular Pericytes in the Generation of Pro-fibrotic Connective Tissue Cells : Investigations in vitro and in Reactive Tissues in vivo

    Author : Jakob Karén; Christian Sundberg; Gunilla Westergren-Thorsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pericyte fibroblast differentiation fibrosis; Biochemistry; Biokemi; Microbiology; Mikrobiologi; Cell biology; Cellbiologi; Medical Biochemistry; Medicinsk biokemi; Cellforskning; Cell Research; Mikrobiologi; Microbiology;

    Abstract : Pericytes are cells of mesenchymal origin located on the abluminal side, juxtapositioned to the endothelial cells in capillaries, venules and small arterioles. They are important for maintaining vessel integrity in resting tissues as well as the formation and stabilization of new vessels. READ MORE