Search for dissertations about: "medicinsk virologi"

Showing result 21 - 25 of 65 swedish dissertations containing the words medicinsk virologi.

  2. 21. The discovery of antiviral compounds targeting adenovirus and herpes simplex virus : assessment of synthetic compounds and natural products

    Author : Mårten Strand; Göran Wadell; Mikael Elofsson; Ya-Fang Mei; Lieve Naesens; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virology; antiviral; adenovirus; herpes simplex virus; small molecule; inhibitor; hsv; drug discovery; medicinsk virologi; Medical Virology; datorlingvistik; computational linguistics; mikrobiologi; Microbiology;

    Abstract : There is a need for new antiviral drugs. Especially for the treatment of adenovirus infections, since no approved anti-adenoviral drugs are available. Adenovirus infections in healthy persons are most often associated with respiratory disease, diarrhea and infections of the eye. These infections can be severe, but are most often self-limiting. READ MORE

  4. 22. Regulation of Adenoviral Gene Expression by the L4-33K and L4-22K Proteins

    Author : Ellenor Backström; Göran Akusjärvi; Francoise Raffalli-Mathieu; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

    Abstract : The splicing pattern during an adenovirus infection is shifted at the late phase towards using weaker splice sites, splicing out larger introns. Splicing of weak 3´ splice sites usually requires recognition of the 3´AG dinucleotide before the first catalytic step of splicing. READ MORE

  5. 23. Cellular and Viral Factors that Control Human Papillomavirus Type 16 Late Gene Expression

    Author : Monika Somberg; Stefan Schwartz; Sheila Graham; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Virologi; Medical Virology; Medicinsk virologi;

    Abstract : Human papillomavirus type 16 (HPV-16) is the major cause of cervical cancer. We speculate that inhibition of HPV-16 late gene expression is a prerequisite for establishment of persistence and progression to cervical cancer. READ MORE

  6. 24. Molecular characterization of the interplay between DNA-PK and TRF2 in telomere protection

    Author : Beatrice Toia; Francisca Lottersberger; Anita Öst; Grazia Daniela Raffa; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The genetic material of mammalian cells is organized as linear chromosomes inside their nucleus. In order to preserve genomic stability, mammalian cells have developed several mechanisms to detect and repair DNA lesions that can occasionally occur in the genome. READ MORE

  7. 25. The glycobiology of human adenovirus infections : implications for tropism and treatment

    Author : Naresh Chandra; Niklas Arnberg; Lars Frängsmyr; Gunnel Haldén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs; GAG-mimetic; obesity; medicinsk virologi; Medical Virology;

    Abstract : Human adenoviruses (HAdVs) are common human pathogens, causing gastrointestinal, ocular, and respiratory infections on a regular basis. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection for which no approved antivirals are available. READ MORE