Search for dissertations about: "megencephaly"

Found 3 swedish dissertations containing the word megencephaly.

  2. 1. The megencephaly mouse : from gene to neuronal proliferation

    Author : Ann-Sophie Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Megalencephaly; epilepsy; mouse model; genetics; voltage gated potassium channel; hippocampus; proliferation;

    Abstract : Megalencephaly, enlarged brain, can be associated with a wide range of symptoms from benign to severe. Severe cases are often associated with mental retardation and seizures. The megencephaly mouse shows a dramatic, progressive increase in size of the hippocampus and ventral cortex. READ MORE

  4. 2. Megencephaly, significance, biology and identification of a genetic cause

    Author : Susanna Petersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Megalencephaly; brain; mceph; ion-channel; DNA; mutation; truncation; frameshift; seizure; plasticity; neurotrophin; growth factor; neuropeptide; positional cloning;

    Abstract : Enlarged brain is termed megencephaly or megalencephaly, and is defined as a brain volume above the 98th percentile. It is a major sign in several neurological diseases with symptoms ranging from very mild to lethal, including mental retardation, low intelligence, motoric and neurological disturbances, seizures and dysmorphic features. READ MORE

  5. 3. Neuropeptide expression in mouse disease models

    Author : Margarita Diez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimers disease; autoradiographic ligand binding; CCK; degeneration; dynorphin; enkephalin; galanin; immunohistochemistry; in situ hybridization; lesion; magnetic resonance imaging; megencephaly; NPY; prion infection; substance P.;

    Abstract : The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still relatively unexplored. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides (and other molecules). READ MORE