Search for dissertations about: "melphalan"
Showing result 1 - 5 of 17 swedish dissertations containing the word melphalan.
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1. Preclinical Studies of the Melphalan Prodrug J1 for Cancer Therapy
Abstract : J1 (L-melphalanyl-L-p-fluorophenylalanyl ethyl ester) is a dipeptide derivative of the alkylating agent melphalan with increased cytotoxicity. In this thesis the preclinical pharmacology of J1 has been characterized.Our results show that J1 rapidly enters the cells, where melphalan is released by hydrolysis. READ MORE
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2. Pathogenesis and treatment of chemical-induced lung injury
Abstract : Inhalation of chemical substances can cause irritation to airways and in high doses acute airway injury. When mice are exposed to the alkylating nitrogen mustard analogue melphalan they develop an acute airway inflammation with a rapid influx of neutrophils to the lungs. READ MORE
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3. Immunological effects of isolated regional perfusion in malignant melanoma
Abstract : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. READ MORE
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4. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy
Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE
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5. AL amyloidosis : Study of epidemiology, diagnosis and treatment with emphasis on heart involvement
Abstract : AL (immunoglobulin light chain) amyloidosis is often associated with delayed diagnosis and thereby high early mortality that is not overcome by contemporary treatment. There is a need for diagnostic methods promoting earlier diagnosis, especially in patients with cardiac involvement. READ MORE