Search for dissertations about: "membrane penetration"

Showing result 11 - 15 of 40 swedish dissertations containing the words membrane penetration.

  2. 11. Biophysical studies of cell-penetrating peptides and of the RNR inhibitor Sml1

    Author : Elsa Bárány-Wallje; Astrid Gräslund; Joachim Seelig; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; transportan; bicelles; Sml1; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : Several short peptides, so called cell-penetrating peptides, have the capability to transport large hydrophilic cargos through the cell membrane. The objective is to use these peptides as drug carriers and thereby enhance the uptake of drugs into cells.Three different cell-penetrating peptides are characterized in this thesis. READ MORE

  4. 12. A theoretical study of 5-Aminolevulinic acid and its esters : properties and lipid permeability

    Author : Edvin Erdtman; Leif Eriksson; Fahmi Himo; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

    Abstract : 5-aminolevulinic acid (5ALA) is a widely used prodrug in Photodynamic therapy (PDT). The target molecule in 5ALA-PDT is Protoporphyrin IX (PpIX), which is synthesized endogenously via the heme pathway in the cell. READ MORE

  5. 13. Rational design and applications of cell-penetrating peptides

    Author : Jakob Regberg; Ülo Langel; Amelie Eriksson Karlström; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Cell-penetrating peptides are peptides capable of translocating the cellular membrane and entering the cell, either alone or together with a cargo. Potential applications of cell-penetrating peptides include drug delivery and gene therapy. READ MORE

  6. 14. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

    Author : Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

    Abstract : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. READ MORE

  7. 15. Assembly and entry mechanisms of Semliki Forest virus

    Author : Bernd Uwe Barth; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Semliki Forest virus; virus assembly; protein oligomerization; virus budding;

    Abstract : The genomes of enveloped viruses are packaged into a core or nucleocapsid (NC) which is surrounded by a lipid membrane with spike proteins. These viruses mature by budding at a membrane of the host cell, usually the plasma membrane (PM), and penetrate into new ones by a virus-host membrane fusion event. READ MORE