Search for dissertations about: "membrane permeability"

Showing result 1 - 5 of 123 swedish dissertations containing the words membrane permeability.

  1. 1. Intestinal absorption of drugs The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Carl Roos; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE

  2. 2. Free Volume and Mesopores in Polymer Nanocomposites

    University dissertation from KFS AB

    Author : Petra Winberg; Lunds universitet.; Lund University.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical technology and engineering; Kompositmaterial; Composite materials; Macromolecular chemistry; permeability ; membrane ; positron annihilation ; fumed silica ; clay ; mesopores ; polymer nanocomposites ; free volume ; Kemiteknik och kemisk teknologi; Makromolekylär kemi;

    Abstract : Popular Abstract in Swedish Den fria volymen i en polymer är kopplad till flera fundamentala fysikaliska egenskaper som till exempel densitet, viskositet och gas diffusivitet. De fysikaliska egenskaperna hos polymerer i närheten av, eller i kontakt med, en solid yta har visats vara väsentligt olika dess bulkegenskaper. READ MORE

  3. 3. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Pär Matsson; Uppsala universitet.; [2007]
    Keywords : Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

    Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE

  4. 4. Characterization of artificial and biological lipid vesicles using TIRF and SPR

    University dissertation from ; Chalmers tekniska högskola; Gothenburg

    Author : Thomas Olsson; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane permeability; chromaffin vesicle; fluorescence; total internal reflection TIRF microscopy; surface plasmon resonance SPR ; vesicle; osmotic shock; cell membrane; liposome; nanoparticle tracking analysis NTA ; large dense core vesicles LDCVs ;

    Abstract : Synthetic lipid vesicles serve as important mimics of cells and the natural membranes that they are enclosed by. As such they are frequently used as simplified models of the highly complex cell membrane to aid in-depth physicochemical and biological characterization of this essential biological structure. READ MORE

  5. 5. Intestinal Permeability and Presystemic Extraction of Fexofenadine and R/S-verapamil

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christer Tannergren; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Bioavailability; Fexofenadine; Verapamil; P-glycoprotein; CYP3A4; OATP; Enantioselective; Permeability; Caco-2; Intestinal perfusion; Biofarmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci;

    Abstract : The main objective of this thesis was to investigate the in vivo relevance of membrane transporters and cytochrome P450 (CYP) 3A4-mediated metabolism in the intestine and liver for the bioavailability of drugs in humans after oral administration.In the first part of the thesis, the main transport mechanisms involved in the intestinal absorption and bioavailability were investigated for fexofenadine, a minimally metabolized drug, which is a substrate for P-glycoprotein (P-gp) and members of organic anion transporting polypeptide (OATP) family. READ MORE