Search for dissertations about: "membrane protein design"

Showing result 1 - 5 of 74 swedish dissertations containing the words membrane protein design.

2. 1. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins

   Author : Linda Dexlin Mellby; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scFv; membrane proteins; proteomics; protein chip; recombinant antibodies; Antibody microarray; protein profiling; membrane proteomics;

   Abstract : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. READ MORE

4. 2. Tailoring of Biomaterials using Ionic Interactions : Synthesis, Characterization and Application

   Author : Björn Atthoff; Jöns Hilborn; Tim Bowden; Mats Andersson; Uppsala universitet; []
   Keywords : Chemistry; biodegradable polymers; ionomer; water uptake; protein delivery; protein adsorption; protein membrane; cell seeding efficiency; amphiphillic; inner structure; polarized membrane; Kemi;

   Abstract : The interactions between polymers and components of biological systems are an important area of interest within the fields of tissue engineering, polymer chemistry, medicine and biomaterials. In order to create such a biomimetic material, it must show the inherent ability to reproduce or elicit a biological function. READ MORE

5. 3. Insane in the membrane: : Insertion of marginally hyrdophobic transmembrane helices and global analysis of membrane protein topology

   Author : Daniel Nilsson; Arne Elofsson; Susanna Törnroth Horsefield; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

   Abstract : Proteins are responsible for carrying out most of the tasks in a living cell; transcription, translation, replication, movement, catalysis and communication to mention a few. A subset of proteins is the integral membrane proteins, IMPs, which play an important role in governing communication across membranes, whether it is the plasma membrane or an organelle membrane. READ MORE

6. 4. Insight into the mitochondrial apoptotic pathway : The interplay of the pro-apoptotic Bax protein with oxidized phospholipids and its counterplayer, the pro-survival Bcl-2 protein

   Author : Marcus Wallgren; Gerhard Gröbner; Marco Colombini; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; apoptosis; Bax; Bcl-2; CD; cell-free protein synthesis; DSC; membrane; mitochondria; oxidized phospholipids; reconstitution; solid state NMR; biologisk kemi; biological chemistry;

   Abstract : Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and removing harmful cells. The anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and the pro-apoptotic Bcl-2-associated X protein (Bax) act as major regulators of the mitochondrial apoptotic pathway. READ MORE

7. 5. On bacterial formats in protein library technology

   Author : Per-Åke Löfdahl; Per-Åke Nygren; Mikael Widersten; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; β-lactamase; combinatorial library; green fluorescent protein GFP ; protein engineering; protein fragment complementation assay PCA ; selection; TEVprotease; TNF-α; Bioengineering; Bioteknik; Enzyme engineering; Enzymteknik;

   Abstract : Millions of years of evolution have resulted in an immense number of different proteins, which participate in virtually every process within cells and thus are of utmost importance for allknown forms of life. In addition, there are several examples of natural proteins which have found use in applications outside their natural environment, such as the use of enzymes infood industry and washing powders or the use of antibodies in diagnostic, bioseparation or therapeutic applications. READ MORE