Search for dissertations about: "membrane protein insertion"

Showing result 6 - 10 of 69 swedish dissertations containing the words membrane protein insertion.

2. 6. Insane in the membrane: : Insertion of marginally hyrdophobic transmembrane helices and global analysis of membrane protein topology

   Author : Daniel Nilsson; Arne Elofsson; Susanna Törnroth Horsefield; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

   Abstract : Proteins are responsible for carrying out most of the tasks in a living cell; transcription, translation, replication, movement, catalysis and communication to mention a few. A subset of proteins is the integral membrane proteins, IMPs, which play an important role in governing communication across membranes, whether it is the plasma membrane or an organelle membrane. READ MORE

4. 7. The Membrane-Spanning Domain of Complex I Investigated with Fusion Protein Techniques

   Author : Maria Trane; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NuoN; NuoM; NuoL; covalent bound heme; Bacillus subtilis; Escherichia coli; membrane protein; His-tag; Cytochrome c; NADH:quinone oxidureductase; fusion protein;

   Abstract : NADH:quinone oxidoreductase, or complex I, is a large, complex and poorly understood bioenergetic enzyme in the respiratory chain of living organisms. The enzyme has a conserved core structure, comprising fourteen protein subunits: Seven subunits protrude from the membrane and contain a flavin prosthetic group and eight iron-sulfur clusters that guide electrons from the oxidation of NADH towards the quinone binding site(s). READ MORE

5. 8. Solvation properties of proteins in membranes

   Author : Anna CV Johansson; Erik Lindahl; Mounir Tarek; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane protein; lipid bilayer; free energy; solvation; insertion; molecular dynamics simulations; protein mass fraction; Theoretical chemistry; Teoretisk kemi; Biochemistry; biokemi;

   Abstract : Knowledge about the insertion and stabilization of membrane proteins is a key step towards understanding their function and enabling membrane protein design. Transmembrane helices are normally quite hydrophobic to insert efficiently, but there are many exceptions with unfavorable polar or titratable residues. READ MORE

6. 9. What’s in? What’s out? And how did it get there? : Studies on topologies and insertion of membrane proteins

   Author : Marie Österberg; Gunnar von Heijne; Peter Rehling; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; yeast; mitochondria; TIM23; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Because of their hydrophobic and hydrophilic nature and the need for a lipid bilayer for retaining the native structure, membrane proteins are hard to study. Nevertheless, they are important, as many of our diseases are related to membrane proteins and around 60% of the different pharmaceutical drugs are directed against a membrane proteins [1]. READ MORE

7. 10. Cotranslational protein biogenesis in Escherichia coli monitored by force profile analysis

   Author : Felix Nicolaus; Gunnar von Heijne; Ross Dalbey; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; cotranslational protein biogenesis; membrane protein; soluble protein; transmembrane helices; force profile analysis; arrest peptide; biokemi; Biochemistry;

   Abstract : Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. READ MORE