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Showing result 1 - 5 of 28 swedish dissertations matching the above criteria.

2. 1. Dopamine neurons in ventral mesencephalon : interactions with glia and locus coeruleus

   Author : Elisabet Berglöf; Ingrid Strömberg; Stephen B. Dunnett; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; ventral mesencephalon; nerve fiber formation; glia; locus coeruleus; grafting; antioxidant-enriched diet; Histology; Histologi;

   Abstract : Parkinson’s disease is a progressive neurodegenerative disorder, characterized by a depletion of the dopaminergic neurons in the substantia nigra. The cause of the disease is yet unknown but age, oxidative stress, and neuroinflammation are some of the features involved in the degeneration. READ MORE

4. 2. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

   Author : Elin Andersson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

   Abstract : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. READ MORE

5. 3. Somatosensory projection to the mesencephalon : an anatomical study in the cat and monkey

   Author : Mikael Wiberg; Uppsala universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : .... READ MORE

6. 4. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

   Author : Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

   Abstract : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. READ MORE

7. 5. Identification of dopamine neuron progenitors in the embryonic midbrain and stem cell cultures - Studies on the role of neuronal subtype and differentiation state for cell replacemen in a rodent model of Parkinson's disease

   Author : Marie Jönsson; Neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GFP; cell sorting; FACS; Transplantation; ventral mesencephalon; embryonic stem cells;

   Abstract : Parkinson’s Disease (PD) is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements.Currently there is no cure for PD and the available drug treatments only offer symptomatic relief and are often associated with severe side effects. READ MORE