Search for dissertations about: "mesencephalon"

Showing result 11 - 15 of 28 swedish dissertations containing the word mesencephalon.

  2. 11. Intracranial and intraocular grafting of fetal ventral mesencephalic and striatal tissues : neuronal survival and nerve growth characteristics

    Author : Lars Björklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s disease; grafting; ventral mesencephalon; striatum; dopamine; innervation; growth pattem; GDNF; U-74006F;

    Abstract : Parkinson's disease is caused by degeneration of dopaminergic neurons in the ventral mesencephalon. Various animal models and clinical trials has shown that grafts of fetal ventral mesencephalic tissue can survive and functionally reinnervate the dopamine-depleted striatum, leading to long-term improvements of therapeutic value, but still symptomatic relief is far from complete. READ MORE

  4. 12. On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system

    Author : Malin Saga Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dopamine; glia; astrocytes; olfactory ensheathing cells; development; ni-grostriatal; mesencephalon; Parkinson s disease; 6-hydroxydopamine;

    Abstract : Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die motor disturbances in Parkinson's disease, a neurodegenerative disorder where one of the hallmarks is degeneration of dopamine (DA) neurons and concomitant depletion of DA in striatum, can be alleviated by intrastriatal grafting of embryonic DA tissue. READ MORE

  5. 13. Early Rostrocaudal Patterning of the CNS

    Author : Ulrika Nordström; Thomas Edlund; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; CNS development; neural patterning; neural specification; Wnt; FGF; RA; Isthmic organizer; motor neurons; rostrocaudal patterning.; Developmental biology; Utvecklingsbiologi;

    Abstract : The transformation of an initially uniform population of epiblast cells into an intricately complex central nervous system (CNS) is one of the most fascinating processes during embryonic development. Presumptive neural cells are initially specified as cells of forebrain character. READ MORE

  6. 14. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

    Author : Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

    Abstract : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). READ MORE

  7. 15. Development of central catecholaminergic neuronal systems in the lizard Anolis sagrei

    Author : Agneta Rehn; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; double labelling; immunohistochemistry; interplexiform cells; amacrine cells; catecholamines; development; retina; Reptiles; brain; Zoology; Zoologi;

    Abstract : Catecholamines, comprising the neurotransmitters dopamine (DA), noradrenaline (NA) and adrenaline (A) are synthesized by specific enzymes (tyrosine hydroxylase (TH), dopamine ß-hydroxylase (DBH), phenylethanolamine-N-methyltransferase (PNMT)) in the central nervous system. The development and distribution of different catecholaminergic systems have been described in both the brain and retina of the lizard Anolis sagrei. READ MORE