Search for dissertations about: "mesencephalon"

Showing result 16 - 20 of 28 swedish dissertations containing the word mesencephalon.

  2. 16. Transcription factor control in neuronal maintenance and survival

    Author : Banafsheh Kadkhodaei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons is evident in Parkinson s disease, the most frequent neurodegenerative movement disorder. READ MORE

  4. 17. Neurotrophic signalling by GDNF and its receptors

    Author : Miles Trupp; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Many investigators have sought a polypeptide which would alleviate the neuronal loss associated with Parkinson's disease--specifically dopaminergic neurons of the ventral mesencephalon. The survival of this population of neurons has been known for some time to be promoted by soluble factors present in the conditioned media of glial cell lines. READ MORE

  5. 18. Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis

    Author : Simon Agerskov; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; idiopathic normal pressure hydrocephalus; MRI; biomarkers; prediction;

    Abstract : Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement in up to 80% of patients. READ MORE

  6. 19. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

    Author : Gabriele Schierle; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. READ MORE

  7. 20. Cholinergic receptors in human prenetal brain : presence, distribution and influence of nicotine and ethanol

    Author : Lena Falk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Events early in life, including exposure to various compounds, may cause disturbances in brain development. Both maternal smoking and alcohol drinking during pregnancy can induce preand postnatal death, cognitive and neurobehavioral disturbances. READ MORE