Search for dissertations about: "mesencephalon"

Showing result 6 - 10 of 28 swedish dissertations containing the word mesencephalon.

  2. 6. GDNF and alpha-synuclein in nigrostriatal degeneration

    Author : Maria Chermenina; Ingrid Strömberg; Guido Nikkhah; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; GDNF; ventral mesencephalon; lateral ganglionic eminence; alpha-synuclein; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Abstract : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. READ MORE

  4. 7. On dopamine neurons : nerve fiber outgrowth and L-DOPA effects

    Author : Sara af Bjerkén; Ingrid Strömberg; Kathy Steece-Collier; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; GDNF; L-DOPA; L-DOPA induced dyskinesia; Neurobiology; Neurobiologi;

    Abstract : Parkinson’s disease is a disorder mainly characterized by progressive degeneration of dopamine producing neurons in the substantia nigra of the midbrain. The most commonly used treatment strategy is to pharmacologically restore the lost function by the administration of the dopaminergic precursor L-DOPA. READ MORE

  5. 8. Interaction between nerve fiber formation and astrocytes

    Author : Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

    Abstract : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. READ MORE

  6. 9. On transplantation of fetal ventral mesencephalon with focus on dopaminergic nerve fiber formation

    Author : Nina Törnqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : VM; graft; Parkinson s disease; graft reinnervation; striatum; patchy; intraocular transplantation; intracranial transplantation; primary culture;

    Abstract : Poor cell survival and striatal reinnervation are two of the postulated limiting factors of fetal ventral mesencephalic (VM) grafting in Parkinson's disease. It has, however, been reported that an increased survival of VM dopaminergic neurons does not correlate with an enhanced target innervation. READ MORE

  7. 10. The role of Lmx1a and Lmx1b in regulating mesencephalon development and dopamine neuron specification

    Author : Qiaolin Deng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One of the most challenging questions in developmental biology is how neurons are specified, acquire their distinct characteristics and find their correct innervations to form functional circuits. The development of different subsets of neurons involves the expression of a program intrinsic to each cell type and the response to extrinsic environmental influences represented by soluble factors. READ MORE