Search for dissertations about: "mesenchymal stem cell from bone marrow"

Showing result 1 - 5 of 22 swedish dissertations containing the words mesenchymal stem cell from bone marrow.

  2. 1. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Author : Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. READ MORE

  4. 2. Mesenchymal stromal cells in malignant glioma - Functions and therapeutic potential

    Author : Andreas Svensson; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; glioblastoma; mesenchymal stromal cell; pericyte; immunotherapy; interferon-γ;

    Abstract : The most common malignant brain tumor in adults is a glioma called glioblastoma multiforme (GBM). About 300 persons are diagnosed with GBM every year in Sweden. Unfortunately, it is also the most aggressive brain tumor and as of today, it is not possible to cure it. READ MORE

  5. 3. Development of biosynthetic conduits for peripheral nerve repair

    Author : Aleksandra McGrath; Liudmila N Novikova; John Haycock; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthetic conduit; Mesenchymal stem cells; Nerve graft; Nerve tissue engineering; Peripheral nerve injury; Schwann cells;

    Abstract : Peripheral nerve injuries are often associated with significant loss of nervous tissue leading to poor restoration of function following repair of injured nerves. Although the injury gap could be bridged by autologous nerve graft, the limited access to donor material and additional morbidity such as loss of sensation and scarring have prompted a search for biosynthetic nerve transplants. READ MORE

  6. 4. Human Bone Marrow Microenvironment in Health and Disease

    Author : Sandro Bräunig; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

    Abstract : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. READ MORE

  7. 5. Schwann cells and mesenchymal stem cells as promoter of peripheral nerve regeneration

    Author : Maria Cristina Mantovani; Mikael Wiberg; Giorgio Terenghi; Susan Shawcross; Lev Novikov; Liudmila Novikova; John W Haycock; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve regeneration; Schwann cell; adult stem cell; myelin; senescence;

    Abstract : The transplantation of primary Schwann cells (SC) has been shown to improve nerve regeneration. However, to monitor the survival of transplanted cells within the host, a stable labelling method is required. READ MORE