Search for dissertations about: "mesenchymal tumor"

Showing result 16 - 20 of 87 swedish dissertations containing the words mesenchymal tumor.

  2. 16. Hypoxia and Stem Cells in Normal and Tumor Development

    Author : Camilla Niklasson; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; hypoxia; preclinical cancer models; ALDH; HIF-2α; PT2385;

    Abstract : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. READ MORE

  4. 17. Electron Microscopy in Diagnostic Pathology with Reference to Mesenchymal Tumors

    Author : Birgitta Carlén; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; synovial sarcoma; Kaposi´s sarcoma; epithelioid sarcoma; parachordoma; alveolar soft part sarcoma; small cell malignant tumors of childhood and adolescence; cultured cells; surgical specimens; Transmission electron microscopy; fine needle aspiration; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : The experience acquired over a period of 15 years of diagnostic electron microscopy of fine needle aspirates and surgical specimens constitutes the base for this thesis. Some of the tumors analyzed represent rare soft tissue tumors, and consequently not very often ultrastructurally described. READ MORE

  5. 18. TGFβ and LXR signaling in hepatocellular carcinoma

    Author : Claudia Bellomo; Aristidis Moustakas; Lars Holmgren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Abstract : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). READ MORE

  6. 19. Mesenchymal stem cells in vascular structure and remodeling in cancer

    Author : Ewa Kurzejamska; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mesenchymal stem cells (MSCs) are present in vascular structure and play an important role in vessel remodeling in normal, as well as pathological conditions, such as transplant arteriosclerosis or tumor angiogenesis. Moreover, MSCs affect tumor growth and metastasis by production of chemokines, such as (C-C motif) ligand 7 (CCL7). READ MORE

  7. 20. Studies of PDGF receptor signaling in vitro and in vivo

    Author : Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Abstract : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. READ MORE