Search for dissertations about: "mesenchymal tumour"

Showing result 1 - 5 of 22 swedish dissertations containing the words mesenchymal tumour.

2. 1. MESENCHYMAL STEM- AND STROMAL CELLS IN BONE MARROW AND OSTEOSARCOMA

   Author : Jan Claas Brune; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mesenchymal stem cells; stromal cells; bone marrow stem cells; tumour stroma; stroma-directed anti-tumour therapy; osteosarcoma;

   Abstract : Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. READ MORE

4. 2. Computational Analysis of Tumour Heterogeneity

   Author : Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. READ MORE

5. 3. Studies of Mesenchymal Progenitor Cells and Tumour Growth, Integrins and Matrix Metalloproteinases

   Author : Lars Bryngelsson Ohlsson; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Tumour inhibition; cancer; onkologi; cancerology; Cytologi; oncology; Cytology; Biologi; Biology; Medicin människa och djur ; Medicine human and vertebrates ; Integrin matrix metalloproteinase interaction; Immunologi; serologi; transplantation; Proteins; enzymology; Proteiner; enzymologi; serology; Mesenchumal progenitor cells;

   Abstract : In this thesis we characterize the effect of mesenchymal progenitor cells (MPCs) on tumour growth, and show that MPCs can have inhibitory effects on tumour development. We developed a method to subcutaneously transplant tumour cells, cultured in vitro in a pre-formed gelatin matrix, that made it possible to study the early phases of tumour development. READ MORE

6. 4. Importance of Hyaluronan Metabolism and Signalling in Tumour Progression

   Author : Berit Bernert; Paraskevi Heldin; Peter Prehm; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; cancer; growth factors;

   Abstract : Hyaluronan, an unbranched glycosaminoglycan of the extracellular matrix, has an amazingly simple structure. Initially thought to fulfil only hydrating and space-filling functions in tissues, evidence generated during the past decades shows that hyaluronan is involved in intriguingly complex signalling events in health and disease. READ MORE

7. 5. Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

   Author : Giulia Pizzolato; Stefan Koch; Åsa Keita; Boudewijn Burgering; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; FOX proteins; Wnt signalling; p53; Tumour biology; Transcription factors; Proteine FOX; Via di segnalazione Wnt; p53; Biologia dei tumori; Fattori di trascrizione;

   Abstract : Wnt/β-catenin signalling, also referred to as canonical Wnt signalling, is a critical regulator of tissue homeostasis and of the differentiation of cells during development. The outcome of canonical Wnt pathway activity is defined by the regulation of target gene transcription, which ultimately determines cell identity and proliferation. READ MORE