Search for dissertations about: "metabolic profiling"

Showing result 16 - 20 of 66 swedish dissertations containing the words metabolic profiling.

  2. 16. Physiological consequences of Elongator complex inactivation in Eukaryotes

    Author : Tony Karlsborn; Anders Byström; Hans Ronne; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Elongator complex; wobble uridine modifications; IKBKAP; IKAP; Familial dysautonomia; Untargeted Metabolic profiling.; molekylärbiologi; Molecular Biology;

    Abstract : Mutations found in genes encoding human Elongator complex subunits have been linked to neurodevelopmental disorders such as familial dysautonomia (FD), rolandic epilepsy and amyotrophic lateral sclerosis. In addition, loss-of-function mutations in genes encoding Elongator complex subunits cause defects in neurodevelopment and reduced neuronal function in both mice and nematodes. READ MORE

  4. 17. Estrogen signaling in metabolic disease : a functional genomics approach

    Author : Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Abstract : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. READ MORE

  5. 18. Transcriptome profiling and gene editing for biofortification of cassava

    Author : Priscilla Olukola Olayide; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Cassava (Manihot esculenta Crantz) is an important food crop for millions of people in sub- Saharan Africa. Cassava serves as a food security crop and a good source of energy, but it has relatively low nutritional quality, which has nutritional implications for those who rely on the crop as their main source of calorie intake. READ MORE

  6. 19. Disturbed Islet Function and Alterations in Islet Protein Expression

    Author : Henrik Ortsäter; Peter Bergsten; Franz Schuit; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; islet; glucose; oleate; corticosterone; oxygen tension; insulin release; protein profiling; Clark-like electrodes; SELDI-TOF MS; PPI-B; 11β-HSD1; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Pancreatic β-cells sense the concentration of glucose in the systemic circulation through metabolism of the sugar molecule. Failure to correlate the blood sugar concentration to an appropriate metabolic signal disrupts the function of the β-cell as a controller of glucose homeostasis and may contribute to the development of type 2 diabetes mellitus. READ MORE

  7. 20. Molecular mechanisms of estrogen action in relation to metabolic disease

    Author : Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. READ MORE