Search for dissertations about: "metabolite profile"

Showing result 1 - 5 of 38 swedish dissertations containing the words metabolite profile.

2. 1. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process

   Author : Malin Nilsson Broberg; Mikael Hedeland; Ulf Bondesson; Curt Pettersson; Börje Tidstedt; Peter Van Eenoo; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; UHPLC-HRMS; Doping control; Metabolite profile; SARM; Selective Androgen Receptor Modulator; MVDA; Microsomes; Experimental design; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

   Abstract : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. READ MORE

4. 2. Pharmacokinetic, efficacy and safety modeling of new treatments against drug-resistant tuberculosis

   Author : Lénaïg Tanneau; Mats Karlsson; Elin Svensson; Italo Poggesi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; nonlinear mixed effect models; tuberculosis; drug-resistance; bedaquiline; delamanid; metabolite; drug-drug interactions; QTc interval; transaminases; time-to-positivity; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Tuberculosis (TB) is an ancient infectious disease that remains one of the greatest killers on the planet. Its eradication is impeded by the development of resistance to first-line treatment. Each year half a million patients are infected with drug-resistant (DR) TB. READ MORE

5. 3. Quantitative influence of exogenous androgens on serum lipid profile and endocrine functions

   Author : Nina Gårevik; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Anabolic androgenic steroids (AAS) in doping have been a concern predominantly in sports. The focus has now switched to the doping in the society which is a significant problem for the public health. The abuse of AAS is associated with mental and somatic side effects and with the use of several other drugs including narcotics. READ MORE

6. 4. Endocrine profile in female Olympic athletes : of importance for physical performance and impact on anti-doping testing

   Author : Emma Eklund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Endogenous androgens and insulin-like growth factor-I (IGF-I) are anabolic hormones that may contribute to increased muscle mass and possibly enhanced athletic performance. Furthermore, the second to fourth digit ratio (2D:4D ratio), suggested as an indirect measurement of prenatal androgen exposure, has been related to athletic ability. READ MORE

7. 5. Metabolic profiling of meat and fish and their impact on human metabolism

   Author : ANDREW VINCENT; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Foodomics; meat; herring; metabolomics; fish;

   Abstract : High intake of meat is frequently associated with increased risk of disease, while the opposite is true for fish; yet few studies have compared meat and fish in terms of both its composition of low-molecular weight (LMW) molecules and its effects on metabolite concentrations in humans. The work presented in this thesis aimed to use metabolomics to get a holistic overview of compositional differences between fish and meat, and the effects of dietary fish or meat intake on human metabolism. READ MORE