Search for dissertations about: "metabolomics"

Showing result 16 - 20 of 144 swedish dissertations containing the word metabolomics.

  2. 16. Towards an Earlier Detection of Progressive Multiple Sclerosis using Metabolomics and Machine Learning

    Author : Stephanie Herman; Kim Kultima; Ola Spjuth; Joachim Burman; Johan Lengqvist; Camilla Svensson; Gabi Kastenmüller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bioinformatics; biomarkers; progressive multiple sclerosis; metabolomics; machine learning; advanced analytics; mass spectrometry;

    Abstract : Decision-making guided by advanced analytics is becoming increasingly common in many fields. Implementing computationally driven healthcare solutions does, however, pose ethical dilemmas as it involves human health. READ MORE

  4. 17. Development of advanced chemical biology tools for microbiome metabolism : Chemoselective probes for enhanced metabolomics analysis

    Author : Weifeng Lin; Daniel Globisch; Frank Schroeder; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemical biology; Chemoselective modification; Chemical metabolomics; Bioorganic; Microbiome metabolism; Kemi; Chemistry;

    Abstract : The human microbiome has a profound impact on host physiology by generating highly reactive compounds that can contribute to the development of diseases. These microbial metabolites have a substantial potential that can serve as valuable indicators or biomarkers for different health conditions. READ MORE

  5. 18. Multi-platform metabolomics assays to study the responsiveness of the human plasma and lung lavage metabolome

    Author : Masoumeh Karimpour; Malin Nording L.; Magnus Åberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LC MS; GC MS; NMR; metabolomics; metabolite; exposure; postprandial; plasma; lung lavage; BW; BW; data analysis; univariate analysis; multivariate analysis;

    Abstract : Metabolomics as a field has been used to track changes and perturbations in the human body by investigating metabolite profiles indicating the change of metabolite levels over time and in response to different challenges. In this thesis work, the main focus was on applying multiplatform-metabolomics to study the human metabolome following exposure to perturbations, such as diet (in the form of a challenge meal) and exhaust emissions (air pollution exposure in a controlled setting). READ MORE

  6. 19. Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia

    Author : Jenny Hadrévi; Albert Crenshaw; Fatima Pedrosa-Domellöf; Fredrik Hellström; Bijar Ghafouri; Mary F Barbe; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Trapezius myalgia; proteomics; 2D-DIGE; metabolomics; microdialysate; biopsies; anatomi; Human Anatomy;

    Abstract : Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. READ MORE

  7. 20. Damsel in distress – metabolomics as a novel tool to investigate the effects of wastewater exposure on damselfly larvae

    Author : Jana Späth; Malin L. Nording; Jerker Fick; Stina Jansson; Tuulia Hyötyläinen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biomarkers; ecotoxicology; invertebrates; GC-MS; LC-MS; LC-MS MS; metabolomics; micropollutants; pharmaceuticals; risk assessment; ekotoxikologi; Ecotoxicology; Analytical Chemistry; analytisk kemi;

    Abstract : Aquatic organisms, such as aquatic invertebrates, are exposed to anthropogenic pollutants through their environment. These pollutants, despite their low levels, can adversely affect exposed individuals or even entire ecosystems, especially when present in complex mixtures. READ MORE