Search for dissertations about: "metalloenzyme"

Showing result 1 - 5 of 12 swedish dissertations containing the word metalloenzyme.

  2. 1. Characterization of two novel fatty acid dioxygenases : Linoleate diol synthase and manganese lipoxygenase

    Author : Chao Su; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Dioxygenase; hemeprotein; lipoxygenase; metalloenzyme; oxylipin; fatty acid; manganese-protein; Gaeumannomyces graminis; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Two classes of fatty acid dioxygenases, PGH synthases (hemeproteins) and lipoxygenases (non-heme iron proteins), are of eminent pharmacological importance. This thesis describes a PGH synthase-related dioxygenase designated linoleate diol synthase (LDS) and the first native occurring manganese-containing lipoxygenase. READ MORE

  4. 2. Asymmetric transformation of ß- and γ-functionalized alcohols : Study of combined ruthenium-catalyzed racemization and enzymatic resolution

    Author : Annika Träff; Jan-Erling Bäckvall; Reko Leino; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Abstract : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution. The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. READ MORE

  5. 3. Outer Coordination Spheres Engineering of Ru-based Molecular Water Oxidation Catalysts

    Author : Tianqi Liu; Licheng Sun; Julio Lloret-Fillol; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; solar fuels; water oxidation; catalysis; ruthenium complex; Ru-bda; Ru-pda; outer coordination sphere; hydrophobic interactions; Kemi; Chemistry;

    Abstract : The outer coordination sphere plays a vital role in metalloenzyme catalysis, while this principle is relatively less considered in the design of man-made molecular catalysts. This thesis investigates the role of outer coordination spheres in water oxidation by a series of ruthenium-based complexes. READ MORE

  6. 4. Evolution and structure of leukotriene A4 hydrolase

    Author : Filippa Kull; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotriene (LT) B4 is a potent leukocyte chemotactic and aggregating agent involved in a variety of inflammatory and allergic disorders. The enzyme leukotriene A4 hydrolase catalyzes the hydrolysis of LTA4 into this proinflammatory mediator, leukotriene B4. READ MORE

  7. 5. Transition Metal-Catalyzed Redox Reactions : A Journey from Homogeneous Ruthenium to Heterogeneous Palladium Catalysis

    Author : Oscar Verho; Jan-Erling Bäckvall; Manfred Reetz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organisk kemi; Organic Chemistry;

    Abstract : The first part of the thesis covers the development and utilization of electronically modified (pentaarylcyclopentadienyl)Ru-complexes in the racemization of secondary alcohols. This study revealed that the electronic properties of the substrate were the main factors dictating whether β-hydride elimination or hydride re-addition becomes the rate-determining step of the racemization process. READ MORE