Search for dissertations about: "metalloproteases MMPs"
Found 5 swedish dissertations containing the words metalloproteases MMPs.
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1. rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
Abstract : The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a retina degeneration which starts around day 10 with rod photoreceptor cell death. READ MORE
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2. Matrix metalloproteases and cell motility in malignant mesothelioma
Abstract : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. READ MORE
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3. Studies of cell migration and matrix protease production in human lung cancer cell lines
Abstract : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. READ MORE
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4. Matrix degrading proteases in the ovary : expression and function
Abstract : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. READ MORE
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5. TGFβ Signal Transduction in Endothelial Cells
Abstract : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. READ MORE