Search for dissertations about: "metalloproteinase- 1"
Showing result 1 - 5 of 72 swedish dissertations containing the words metalloproteinase- 1.
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1. Extracellular matrix remodelling proteases in acute appendicitis and their impact on appendiceal perforation
Abstract : Abstract Background Appendicitis is associated with varying degradation of extracellular matrix involved in tissue injury. The principal aim of this study was to investigate whether immunoreactive techniques could illustrate the course and severity of appendicitis and separate the different inflammatory grades, phlegmonous, gangrenous and perforated appendicitis, from each other and from uninflamed appendix. READ MORE
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2. Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways
Abstract : Migration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. READ MORE
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3. Biomolecular Aspects of Flexor Tendon Healing
Abstract : Flexor tendon injuries in zone II of the hand (i.e. between the distal volar crease and the distal interphalangeal joint) can be costly for both the afflicted individual and society because of the high cost of a long rehabilitation period, complicated by tendon ruptures or scarring with adhesion formation, causing impaired range of motion. READ MORE
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4. Rectal Cancer - Tumor Biology and Prognostic Markers
Abstract : Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. READ MORE
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5. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology
Abstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE