Search for dissertations about: "metalloproteinases"

Showing result 6 - 10 of 82 swedish dissertations containing the word metalloproteinases.

  2. 6. Immune regulation in multiple sclerosis : cytokines and metalloproteinases

    Author : Volkan Özenci; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Immunological mechanisms play a central role in the pathogenesis sclerosis (MS). In this study two groups of related immune variables are cytokines and metalloproteinases (MMPs), which regulate each other's production and activation. READ MORE

  4. 7. Bowel irradiation: the effects on inflammation and matrix-metalloproteinases

    Author : ANDREA POLISTENA; Kirurgi; []
    Keywords : Radiotherapy; Inflammation; Colorectal Cancer; MMP-7; Matrilysin; Bacteria;

    Abstract : Background and aims: Radiotherapy is a valid treatment in cancer multimodal management but it is affected by severe systemic and local side effects. A murine small bowel model was used for the investigation of inflammatory features and apoptosis of local radiotherapy. READ MORE

  5. 8. Towards surgical use of matrix metalloproteinase biology

    Author : Björn Pasternak; Per Aspenberg; Pentti Tengvall; Yrjö T Konttinen; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; Orthopaedics; Ortopedi;

    Abstract : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. READ MORE

  6. 9. Experimental Colonic Obstruction and Anastomotic Healing

    Author : Martin Rehn; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstruction; anastomosis; colon; wound healing; matrix metalloproteinases; collagen; MMP inhibition;

    Abstract : Colorectal cancer is one of the most common malignant diseases world-wide. Most patients can be diagnosed, staged and treated by surgery in an elective setting. However, about one fifth of the patients will have an emergency presentation and in most cases due to malignant obstruction of the left colon. READ MORE

  7. 10. Effects of sex steroids and tamoxifen on matrix metalloproteinase activity and generation of endostatin in the breast

    Author : Ulrika W. Nilsson; Charlotta Dabrosin; Lena Claesson-Welsh; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Breast cancer; TGF-β1; Endostatin; Estradiol; Mammary gland; Matrix metalloproteinases; MCF-7; Microdialysis; Nude mice; Tamoxifen; Oncology; Onkologi;

    Abstract : Sex steroids are inevitable in women. However, long-term exposure to sex steroids increases the risk of breast cancer. A complete understanding of sex steroid control of the breast and how it relates to breast cancer risk is still lacking. READ MORE