Search for dissertations about: "metastatic bone cancer therapy"

Showing result 1 - 5 of 19 swedish dissertations containing the words metastatic bone cancer therapy.

2. 1. Prostate cancer and bone cell interactions : implications for metastatic growth and therapy

   Author : Annika Nordstrand; Pernilla Wikström; Anders Widmark; Jonas Nilsson; Päivi Östling; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; Oncology;

   Abstract : The skeleton is the most common site of prostate cancer bone metastasis, and at present, there are no curable treatments for these patients. To further understand what stimulates tumor cell growth in the bone microenvironment and to find suitable therapies, reliable model systems are needed. READ MORE

4. 2. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

   Author : Siker Kimbung; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

   Abstract : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. READ MORE

5. 3. Metastatic spinal cord compression in prostate cancer : clinical and morphological studies

   Author : Sead Crnalic; Richard Löfvenberg; Anders Widmark; Anders Bergh; Sten Nilsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; bone metastasis; spinal cord compression; surgical treatment; survival prognosis; early diagnosis; androgen receptor; Orthopaedics; ortopedi; Pathology; patologi; Oncology; onkologi;

   Abstract : Background: Bone metastases occur in most patients with advanced hormone-refractory prostate cancer causing pain, pathologic fractures, and spinal cord compression. Few studies specifically address surgical treatment of metastatic spinal cord compression (MSCC) in prostate cancer. READ MORE

6. 4. Molecular heterogeneity of prostate cancer bone metastasis

   Author : Erik Bovinder Ylitalo; Pernilla Wikström; Anders Bergh; Maria Brattsand; Vessela Kristensen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; CRPC; castration-resistant; androgen receptor; splice variant; abiraterone; cabazitaxel; ABCB1; cholesterol; Mdr1; P-gp; bone metastasis; immune response; metabolism; osteoblast; osteoclast; BMP; methylation;

   Abstract : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. READ MORE

7. 5. MicroRNA expression profiles in prostate cancer bone metastases : functional effects of microRNA-23c, -375, and -4328

   Author : Helena Järemo; Pernilla Wikström; Maria Brattsand; Anders Bergh; Elin Thysell; Guido Jenster; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer bone metastases; microRNA; metastatic subtypes; extracellular vesicles; Pathology; patologi;

   Abstract : Non-coding microRNAs (miRNAs) function as post-transcriptional regulators of gene expression by interacting with messenger RNA. Dysregulation of miRNAs has many possible consequences, including tumor-suppressive or -promoting ones, and restoring or preventing the effects of miRNA alteration has therapeutic potential. READ MORE