Search for dissertations about: "metformin"

Showing result 6 - 10 of 34 swedish dissertations containing the word metformin.

  2. 6. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

    Author : Sarah Piel; Klinisk neurofysiologi; []
    Keywords : mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

    Abstract : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. READ MORE

  4. 7. Esophageal squamous cell carcinoma : opportunities for prevention

    Author : Qiaoli Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype of esophageal cancer, a highly fatal malignant neoplasm. Most ESCC patients are diagnosed at a late stage when tumors are unresectable or have metastasized. READ MORE

  5. 8. Consequences of inadequate use of glucose lowering drugs and associated risk factors

    Author : Lotta Walz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes Mellitus is characterized by chronically elevated blood glucose levels, hyperglycaemia. Consistent adherence to appropriate glucose-lowering drug therapy is fundamental to prevent disease progression, diabetes-related complications and premature death. READ MORE

  6. 9. Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells

    Author : Camilla Kappe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral tissues. READ MORE

  7. 10. Potential therapies and biomarkers for LAMA2-CMD. Does the microRNA hype deliver?

    Author : Bernardo Moreira Soares Oliveira; Muskelbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskeldystrofi; genetic-markers; Small non-coding RNAs;

    Abstract : Laminin α2 chain-deficient muscular dystrophy, or LAMA2-CMD, is a very severe disease caused by mutations in the LAMA2 gene. Skeletal muscle is the most affected tissue, with patients presenting symptoms such as hypotonia at birth, joint contractures and progressive muscle wasting. READ MORE