Search for dissertations about: "method validation protocol"

Showing result 1 - 5 of 21 swedish dissertations containing the words method validation protocol.

  2. 1. Development of analytical methods for the determination of the small molecule component of complex biological systems

    Author : Kristian Pirttilä; Mikael Hedeland; Curt Pettersson; Torbjörn Arvidsson; Thomas Moritz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolomics; data processing; peak characterization; algorithm; multivariate data analysis; chromatography; sequential columns; HILIC; RPLC; liquid chromatography; mass spectrometry; LC; MS; noise-induced hearing loss; NIHL; guinea pig; perilymph; method development; validation; R; C ; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : The research field of untargeted metabolomics aims to determine the relative abundance of all small metabolites in a biological system in order to find biomarkers or make biological inference with regards to the internal or external stimuli. This is no trivial aim, as the small metabolites are both vast in numbers and extremely diverse in their chemical properties. READ MORE

  4. 2. Multi-element analysis of environmental samples using LA-ICP-MS : method developments with emphasis on calibration strategies

    Author : Mikael D. Axelsson; Luleå tekniska universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Applied Geology; Tillämpad geologi;

    Abstract : Analytical applications based on the use of laser ablation-inductively coupled plasma-sector field mass spectrometry (LA-ICP-SFMS) have shown great potential for both quantitative and qualitative determination of elements in a variety of materials, although the weak point is finding a suitable calibration approach. The major focus of this work has, therefore, been internal standardisation and calibration. READ MORE

  5. 3. Advances in quantitative emission tomography : development and analysis of methods for validation and correction

    Author : Cathrine Jonsson; Magnus Dahlbom; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SPECT; Quantification; rCBF; Scatter correction; Phantoms; medicinsk strålningsfysik; Medical Radiation Physics;

    Abstract : The nuclear medicine imaging techniques SPECT and PET are sensitive tools in mapping various physiological and biochemical processes in vivo. This work was devoted to investigations of methodological and physical properties of the SPECT technique as well as developing methods for validation and correction. READ MORE

  6. 4. International validation of the comet assay and a human intervention study

    Author : Clara Ersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The comet assay is an established, sensitive method extensively used in biomonitoring studies. The methods’ advantages include; a) only a small cell sample is required, b) possibility to measure damage in practically any cell type, c) ability to measure heterogeneity in response within a cell population, d) relatively fast and economical procedure, and e) various applications of the method, which allow measurement of a range of different DNA lesions as well as DNA repair. READ MORE

  7. 5. Pulmonary embolism : validation of diagnostic imaging methods in the clinical setting

    Author : Tage Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Computed tomography; lung scintigraphy; pulmonary arteriography; pulmonary embolism; D-dimer;

    Abstract : Pulmonary embolism (PE) is an elusive diagnosis and none of the existing imaging modalities have a 100% diagnostic specificity or sensitivity. Pulmonary arteriography (PA) is the most specific test although the improvement of computed tomography technique has made this a commonly used method. Lung scintigraphy often gives ambiguous results. READ MORE